RNA-mediated gene activation

被引：61
|
作者：
Jiao, Alan L. [1 ]
Slack, Frank J. [1 ]
机构：
[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
来源：
EPIGENETICS | 2014年 / 9卷 / 01期
关键词：
transcriptional activation; saRNA; RNAa; non-coding RNA; eRNA; lincRNA; epigenetic; enhancer; LONG-NONCODING-RNA; EPIGENETIC MEMORY; TRANSCRIPTIONAL ACTIVATION; ANTISENSE TRANSCRIPTS; ARGONAUTE PROTEINS; NATURAL ANTISENSE; RESPONSE ELEMENTS; EXPRESSION; CHROMATIN; BIOGENESIS;
D O I：
10.4161/epi.26942
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The regulation of gene expression by non-coding RNAs (ncRNAs) has become a new paradigm in biology. RNA-mediated gene silencing pathways have been studied extensively, revealing diverse epigenetic and posttranscriptional mechanisms. In contrast, the roles of ncRNAs in activating gene expression remains poorly understood. In this review, we summarize the current knowledge of gene activation by small RNAs, long non-coding RNAs, and enhancer-derived RNAs, with an emphasis on epigenetic mechanisms.
引用
收藏
页码：27 / 36
页数：10
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