Prognostic value of the IASLC/ATS/ERS classification in stage I lung adenocarcinoma patients-Based on a hospital study in China

被引:71
作者
Song, Z. [1 ,2 ]
Zhu, H. [2 ,3 ]
Guo, Z. [2 ,3 ]
Wu, W. [2 ,3 ]
Sun, W. [2 ,3 ]
Zhang, Y. [1 ,2 ]
机构
[1] Zhejiang Canc Hosp, Dept Chemotherapy, Hangzhou 310022, Zhejiang, Peoples R China
[2] Key Lab Diag & Treatment Technol Thorac Oncol, Hangzhou 310022, Zhejiang, Peoples R China
[3] Zhejiang Canc Hosp, Dept Pathol, Hangzhou 310022, Zhejiang, Peoples R China
来源
EJSO | 2013年 / 39卷 / 11期
关键词
Non-small cell lung cancer; IASLC/ATS/ERS classification; Prognosis; INTERNATIONAL ASSOCIATION; HISTOLOGIC SUBTYPE; CANCER; RECURRENCE; MUTATIONS; RESECTION; SURVIVAL; IMPACT; EGFR;
D O I
10.1016/j.ejso.2013.08.026
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aims: We investigated the relationship between predominant subtype, according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Lung Adenocarcinoma Classification, and prognosis in stage I lung adenocarcinoma in Zhejiang Cancer Hospital. Methods: Two hundred and sixty-one patients with stage I lung adenocarcinoma, operated in Zhejiang Cancer Hospital, were identified between 2000 and 2010. Survival curves were plotted using the Kaplan-Meier method. The Cox proportional hazard model was used for multivariate analysis. Results: None of the cases were adenocarcinoma in situ and six were minimally invasive adenocarcinomas. Two hundred and fifty-five cases were invasive adenocarcinoma. Of those, 80, 76, 42, 34, 19, and 4 were papillary predominant, acinar predominant, micropapillary predominant, solid predominant, lepidic predominant subtypes, and variants of invasive adenocarcinoma, respectively. Patients with micropapillary and solid predominant tumors had a significantly worse disease-free survival as compared to those with other subtypes predominant tumors (p < 0.001). Multivariate analysis revealed that the new classification was an independent predictor of the disease-free and overall survival (p = 0.002 and 0.015). Conclusion: The predominant subtype in the primary tumor was associated with prognosis in resected stage I lung adenocarcinoma. Published by Elsevier Ltd.
引用
收藏
页码:1262 / 1268
页数:7
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