Studies on fungal metabolites have produced an overwhelming expectation concerning the production of novel bioactive compounds for pharmaceutical applications. The adding of various biosynthetic precursors and the changing of nutritional components in the fermentation medium can change biosynthesis pathways, also leading to the production of novel metabolites. In addition, several growing conditions can be classically manipulated to modify fungal metabolite profiles. Recently, modern genome sequence tools have shown that not all gene clusters are regularly expressed in conventional growing conditions, thus expanding the possibilities of modulating the chemical metabolite profiles produced by filamentous fungi. This review discusses and exemplifies classical and epigenetic tools successfully applied to diversify metabolite production and to produce fungal metabolites from silent metabolic pathways.
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Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Asai, Teigo
Yamamoto, Takashi
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Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Yamamoto, Takashi
Chung, Yu-Ming
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Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, TaiwanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Chung, Yu-Ming
Chang, Fang-Rong
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Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan
China Med Univ, Coll Chinese Med, Grad Inst Integrated Med, Taichung 40402, TaiwanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Chang, Fang-Rong
Wu, Yang-Chang
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Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, TaiwanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Wu, Yang-Chang
Yamashita, Kouwa
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Tohoku Pharmaceut Univ, Aoba Ku, Sendai, Miyagi 9818558, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Yamashita, Kouwa
Oshima, Yoshiteru
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h-index: 0
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Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Asai, Teigo
Chung, Yu-Ming
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机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, TaiwanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Chung, Yu-Ming
Sakurai, Hiroaki
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Tokyo Inst Technol, Dept Chem & Mat Sci, Meguro Ku, Tokyo 1528551, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Sakurai, Hiroaki
Ozeki, Tomoji
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机构:
Tokyo Inst Technol, Dept Chem & Mat Sci, Meguro Ku, Tokyo 1528551, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Ozeki, Tomoji
Chang, Fang-Rong
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h-index: 0
机构:
Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, TaiwanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Chang, Fang-Rong
Yamashita, Kouwa
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h-index: 0
机构:
Tohoku Pharmaceut Univ, Aoba Ku, Sendai, Miyagi 9818558, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Yamashita, Kouwa
Oshima, Yoshiteru
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Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Asai, Teigo
Yamamoto, Takashi
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机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Yamamoto, Takashi
Oshima, Yoshiteru
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h-index: 0
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Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Asai, Teigo
Yamamoto, Takashi
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h-index: 0
机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Yamamoto, Takashi
Chung, Yu-Ming
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, TaiwanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Chung, Yu-Ming
Chang, Fang-Rong
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan
China Med Univ, Coll Chinese Med, Grad Inst Integrated Med, Taichung 40402, TaiwanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Chang, Fang-Rong
Wu, Yang-Chang
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, TaiwanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Wu, Yang-Chang
Yamashita, Kouwa
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h-index: 0
机构:
Tohoku Pharmaceut Univ, Aoba Ku, Sendai, Miyagi 9818558, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Yamashita, Kouwa
Oshima, Yoshiteru
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Asai, Teigo
Chung, Yu-Ming
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, TaiwanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Chung, Yu-Ming
Sakurai, Hiroaki
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Inst Technol, Dept Chem & Mat Sci, Meguro Ku, Tokyo 1528551, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Sakurai, Hiroaki
Ozeki, Tomoji
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Inst Technol, Dept Chem & Mat Sci, Meguro Ku, Tokyo 1528551, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Ozeki, Tomoji
Chang, Fang-Rong
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, TaiwanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Chang, Fang-Rong
Yamashita, Kouwa
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Pharmaceut Univ, Aoba Ku, Sendai, Miyagi 9818558, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Yamashita, Kouwa
Oshima, Yoshiteru
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Asai, Teigo
Yamamoto, Takashi
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
Yamamoto, Takashi
Oshima, Yoshiteru
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, JapanTohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan