ABC transporter architecture and mechanism: implications from the crystal structures of BtuCD and BtuF

被引：42

作者：

Locher, KP ^{[1
]}

Borths, E

机构：

[1] ETH, Inst Mol Biol & Biophys, CH-8093 Zurich, Switzerland

[2] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

FEBS LETTERS | 2004年 / 564卷 / 03期

关键词：

ABC transporter; crystal structure; transport mechanism;

D O I：

10.1016/S0014-5793(04)00289-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ABC transporters are ubiquitous membrane proteins that facilitate unidirectional substrate translocation across the lipid bilayer. Over the past five years, new crystal structures have advanced our understanding of how ABC transporters couple adenosine triphosphate (ATP) hydrolysis to substrate transport. In the following, we will briefly review the results of these structural investigations and outline their mechanistic implications. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：264 / 268

页数：5

共 34 条

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