Cu(I)-NHC Catalyzed Asymmetric Silyl Transfer to Unsaturated Lactams and Amides

被引：83

作者：

Pace, Vittorio ^{[1
]}

Rae, James P. ^{[1
]}

Procter, David J. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

SI-B BOND; CONJUGATE ADDITION; ORGANIC-SYNTHESIS; PHENYLDIMETHYLSILYL GROUP; ALPHA; BETA-UNSATURATED ACCEPTORS; ENANTIOSELECTIVE SYNTHESIS; SILAFUNCTIONAL COMPOUNDS; SAMARIUM(II) IODIDE; CARBON BOND; SILICON;

D O I：

10.1021/ol4033623

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first asymmetric silylation of unsaturated lactams and amides using Cu(I)-NHC catalysts and PhMe(2)SiBpin has been accomplished. The method has been exploited in an expedient asymmetric synthesis of the (R)-enantiomer of the nootropic drug oxiracetam.

引用

页码：476 / 479

页数：4

共 67 条

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