Cu(I)-NHC Catalyzed Asymmetric Silyl Transfer to Unsaturated Lactams and Amides

被引：83
作者：
Pace, Vittorio [1 ]
Rae, James P. [1 ]
Procter, David J. [1 ]
机构：
[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 02期
基金：
英国工程与自然科学研究理事会;
关键词：
SI-B BOND; CONJUGATE ADDITION; ORGANIC-SYNTHESIS; PHENYLDIMETHYLSILYL GROUP; ALPHA; BETA-UNSATURATED ACCEPTORS; ENANTIOSELECTIVE SYNTHESIS; SILAFUNCTIONAL COMPOUNDS; SAMARIUM(II) IODIDE; CARBON BOND; SILICON;
D O I：
10.1021/ol4033623
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first asymmetric silylation of unsaturated lactams and amides using Cu(I)-NHC catalysts and PhMe(2)SiBpin has been accomplished. The method has been exploited in an expedient asymmetric synthesis of the (R)-enantiomer of the nootropic drug oxiracetam.
引用
收藏
页码：476 / 479
页数：4
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