Dendritic Cell-based Immunotherapy Pulsed With Wilms Tumor 1 Peptide and Mucin 1 as an Adjuvant Therapy for Pancreatic Ductal Adenocarcinoma After Curative Resection: A Phase I/IIa Clinical Trial

被引：28

作者：

Nagai, Kazuhiro ^{[1
]}

Adachi, Tomohiko ^{[2
]}

Harada, Hiroshi ^{[1
]}

Eguchi, Susumu ^{[2
]}

Sugiyama, Haruo ^{[3
]}

Miyazaki, Yasushi ^{[1
,4
]}

机构：

[1] Nagasaki Univ Hosp, Transfus & Cell Therapy Unit, 1-7-1 Sakamoto, Nagasaki 8528501, Japan

[2] Nagasaki Univ Hosp, Dept Surg, Nagasaki, Japan

[3] Osaka Univ, Dept Canc Immunol, Grad Sch Med, Osaka, Japan

[4] Nagasaki Univ, Atom Bomb Dis Inst, Dept Hematol, Nagasaki, Japan

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 10期

关键词：

Pancreatic ductal adenocarcinoma; dendritic cell vaccination; WT1; MUC1; phase I/IIa study; GENE WT1; CANCER; CHEMOTHERAPY; GEMCITABINE; EXPRESSION; OVEREXPRESSION; PROGRESSION; REPRESSION; S-1;

D O I：

10.21873/anticanres.14593

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: We evaluated the safety, feasibility, and preliminary efficacy of Wilms tumor gene 1 (WT1) peptide and Mucin 1 (MUC1)-pulsed dendritic cell (DC) (WT1/MUC1-DC) vaccination as an adjuvant immunotherapy for surgically resectable pancreatic ductal adenocarcinoma (PDA) patients. Patients and Methods: Eligible patients were administered WT1/MUC1-DC vaccination at least seven times every 2 weeks with concomitant adjuvant chemotherapy after surgical resection of PDA. Results: Ten patients were enrolled and no Grade 2 or higher toxicities were associated with DC vaccination. The estimated overall survival (OS) and relapse-free survival (RFS) at 3-years from the time of surgical resection were 77.8% and 35.0%, respectively. Immunohistochemical analysis suggested a possible relationship between induction of WT1-specific cytotoxic T lymphocyte after DC vaccination and higher infiltration of CD3/CD4/CD8 lymphocytes in tumor tissues. Conclusion: WT1/MUC1-DC vaccination in the adjuvant setting was safe and well-tolerated in PDA patients after tumor resection. A large-scale prospective study is warranted to evaluate the clinical benefit of this modality.

引用

页码：5765 / 5776

页数：12

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