Molecular characterization of the bovine GHRL gene

被引：7

作者：

Colinet, Frederic G. ^{[1
]}

Portetelle, Daniel ^{[1
]}

Renaville, Robert ^{[1
]}

机构：

[1] Gembloux Agr Univ, Anim & Microbial Biol Unit, B-5030 Gembloux, Belgium

来源：

ARCHIV FUR TIERZUCHT-ARCHIVES OF ANIMAL BREEDING | 2009年 / 52卷 / 01期

关键词：

GHRL; ghrelin; cattle; polymorphism; sequence; GHRELIN GENE; CATTLE; POLYMORPHISMS; RECEPTOR; PROMOTER; STOMACH; GROWTH;

D O I：

10.5194/aab-52-79-2009

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Bovine ghrelin, a 27 amino acid pepticle, has been identified in oxyntic glands of the abomasum. It is an endogenous ligand for growth hormone secretagogue receptor and stimulates food intake and growth hormone secretion. The bovine GHRL gene was completely sequenced and consists of five exons and four introns. Like mouse and human GHRL genes, we found that the bovine GHRL gene also contains a first non-coding exon of 21 bp. The bovine GHRL gene codes for 116 amino acid pepticle named preproghrelin which contains the ghrelin pepticle and another pepticle similar to obestatin. Sequence analysis revealed eight polymorphisms, which are located in the non-coding sequence of the gene.

引用

页码：79 / 84

页数：6

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