LZ205, a newly synthesized flavonoid compound, exerts anti-inflammatory effect by inhibiting M1 macrophage polarization through regulating PI3K/AKT/mTOR signaling pathway

被引：32

作者：

Bai, Dongsheng ^{[1
]}

Zhao, Yue ^{[1
]}

Zhu, Qin ^{[1
]}

Zhou, Yihui ^{[1
]}

Zhao, Yiqiao ^{[1
]}

Zhang, Taiming ^{[2
]}

Guo, Qinglong ^{[1
]}

Lu, Na ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Jiangsu Key Lab Carcinogenesis & Intervent, State Key Lab Nat Med,Dept Basic Med, 24 Tongjiaxiang, Nanjing 210009, Peoples R China

[2] Beijing Yuying Middle Sch, 14 West St,Wanshou Rd, Beijing, Peoples R China

来源：

EXPERIMENTAL CELL RESEARCH | 2018年 / 364卷 / 01期

基金：

中国国家自然科学基金;

关键词：

LZ205; M1 macrophage polarization; PI3K/AKT/mTOR signaling pathway; Colitis; Peritonitis; NF-KAPPA-B; INFLAMMATORY RESPONSE; CROHNS-DISEASE; CELLS; IBD; COLITIS; EXPRESSION; MONOCYTE; PROTECTS; CANCER;

D O I：

10.1016/j.yexcr.2018.01.033

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Macrophage polarization is involved in the process of inflammation. Regulation of macrophage polarization is considered to be an effective method for the treatment of various inflammatory diseases. In our study, we investigated the potential molecular mechanism of the flavonoid compound LZ205, which exhibits anti-inflammatory property. Results showed that LZ205 significantly reduced M1 macrophage-associated proin-flammatory cytokines secretion by regulating PI3K/AKT/mTOR signaling pathway without affecting M2 macrophage-associated cytokines mRNA levels. In vivo studies showed that 12205 significantly inhibited M1 macrophages polarization in DSS-induced colitis and alum-induced murine peritonitis. Consistent with in vitro studies, LZ205 significantly blocked expression of PI3K, p-AKT and p-mTOR in colon tissues and peritoneal macrophages. Taken together, LZ205 exerts anti-inflammatory effect by inhibiting M1 macrophage polarization via regulating PI3K/AKT/mTOR signaling pathway.

引用

页码：84 / 94

页数：11

共 56 条

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