N-benzylbenzamides: A new class of potent tyrosinase inhibitors

被引：48
作者：
Cho, SJ
Roh, JS
Sun, WS
Kim, SH
Park, KD [1 ]
机构：
[1] Korea Res Inst Biosci & Biotechnol, Lab Cellular Funct Modulator, Taejon 305333, South Korea
[2] Seoul Natl Univ, Sch Earth & Environm Sci, Marine Biotechnol Lab, Seoul 151747, South Korea
[3] HAITAI Confectionary R&D Ctr, Seoul, South Korea
[4] SK Chem, Life Sci R&D Ctr, Div Life Sci, Suwon, South Korea
[5] Nutrex Technol, Seoul 137864, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 10期
关键词：
tyrosinase inhibitor; N-benzylbenzamides; 4-substituted resorcinol; SAR;
D O I：
10.1016/j.bmcl.2006.02.018
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of potent inhibitors of tyrosinase and their structure-activity relationships are described. N-Benzylbenzamide derivatives (1-21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it effectively inhibited the oxidation Of L-DOPA catalyzed by mushroom tyrosinase with an IC50 of 2.2 mu M. (C) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2682 / 2684
页数：3
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