Stereoselective deamination of (5′RS)-5-methyl-2′,3′-isopropylidene adenosine catalyzed by adenosine deaminase:: preparation of diastereomerically pure 5′-methyl adenosine and inosine derivatives

被引：12

作者：

Ciuffreda, P ^{[1
]}

Loseto, A ^{[1
]}

Santaniello, E ^{[1
]}

机构：

[1] Univ Milan, Dipartiment Sci Preclin LITA Vialba, I-20157 Milan, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(02)00080-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Adenosine deaminase from calf intestine catalyzes the stereoselective deamination of (5'S)-5'-methyl-2',3'-isopropylidene adenosine to the corresponding inosine derivative, so that by enzymatic deamination of (5'RS)-5'-methyl-2',3'-isopropylidene adenosine, the diastereomerically pure (5'S)-inosine and the unreacted (5'R)-adenosine derivatives can be efficiently prepared. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：239 / 241

页数：3

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