Lipases as practical biocatalysts

被引：463

作者：

Reetz, MT ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(02)00297-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipases are the most used enzymes in synthetic organic chemistry, catalyzing the hydrolysis of carboxylic acid esters in aqueous medium or the reverse reaction in organic solvents. Recent methodological advancements regarding practical factors affecting lipase activity and enantioselectivity are reviewed. Select practical examples concerning the use of lipases in the production of chiral intermediates are also highlighted.

引用

页码：145 / 150

页数：6

共 72 条

[1] 1-Ethoxyvinyl 2-furoate, an efficient acyl donor for the lipase-catalyzed enantioselective desymmetrization of prochiral 2,2-disubstituted propane-1,3-diols and meso-1,2-diols [J].

Akai, S ;

Naka, T ;

Fujita, T ;

Takebe, Y ;

Kita, Y .

CHEMICAL COMMUNICATIONS, 2000, (16) :1461-1462

[2] Combinatorial and computational challenges for biocatalyst design [J].

Arnold, FH .

NATURE, 2001, 409 (6817) :253-257

[3]

Brenna E, 2001, EUR J ORG CHEM, V2001, P1349

[4] Temperature and solvent effects on enzyme stereoselectivity: inversion temperature in kinetic resolutions with lipases [J].

Cainelli, G ;

De Matteis, V ;

Galletti, P ;

Giacomini, D ;

Orioli, P .

CHEMICAL COMMUNICATIONS, 2000, (23) :2351-2352

[5]

Carrea G, 2000, ANGEW CHEM INT EDIT, V39, P2226

[6] A highly chemo- and stereoselective synthesis of β-keto esters via a polymer-supported lipase catalyzed transesterfication [J].

Córdova, A ;

Janda, KD .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (05) :1906-1909

[7] Molecular basis for enantioselectivity of lipase from Chromobacterium viscosum toward the diesters of 2,3-dihydro-3-(4′-hydroxyphenyl)-1,1,3-trimethyl-1H-inden-5-ol [J].

Gascoyne, DG ;

Finkbeiner, HL ;

Chan, KP ;

Gordon, JL ;

Stewart, KR ;

Kazlauskas, RJ .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (09) :3041-3048

[8] Preparation of new lipases derivatives with high activity-stability in anhydrous media:: adsorption on hydrophobic supports plus hydrophilization with polyethylenimine [J].

Guisan, JM ;

Sabuquillo, P ;

Fernández-Lafuente, R ;

Fernandez-Lorente, G ;

Mateo, C ;

Halling, PJ ;

Kennedy, D ;

Miyata, E ;

Re, D .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2001, 11 (4-6) :817-824

[9]

Gum AG, 2000, CHEM-EUR J, V6, P3714, DOI 10.1002/1521-3765(20001016)6:20<3714::AID-CHEM3714>3.0.CO

[10]

2-Z

← 1 2 3 4 5 6 7 8 →