Expression and function of APP and its metabolites outside the central nervous system

被引：56
作者：
Puig, Kendra L. [1 ]
Combs, Colin K. [1 ]
机构：
[1] Univ N Dakota, Sch Med & Hlth Sci, Dept Pharmacol Physiol & Therapeut, Grand Forks, ND 58203 USA
来源：
EXPERIMENTAL GERONTOLOGY | 2013年 / 48卷 / 07期
关键词：
Beta amyloid; Alzheimer; Amyloid precursor protein; Adipose tissue; Epidermis; Intestine; Muscle; AMYLOID PRECURSOR PROTEIN; MESSENGER-RNA; A-BETA; BRAIN; TISSUES; CELLS;
D O I：
10.1016/j.exger.2012.07.009
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Amyloid precursor protein (APP) derived amyloid beta (A beta) peptides have been extensively investigated in Alzheimer's disease pathology of the brain. However, the function of full length APP in the central nervous system remains unclear. Even less is known about the function of this ubiquitously expressed protein and its metabolites outside of the central nervous system. This review summarizes key aspects of the current understanding of the expression and function of APP and its proteolytic fragments in specific non-neuronal tissues. (C) 2012 Elsevier Inc. All rights reserved.
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收藏
页码：608 / 611
页数：4
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