Pathogenesis of venous ulcer

被引：39
作者：
Comerota, Anthony [1 ]
Lurie, Fedor [1 ]
机构：
[1] Jobst Vasc Inst, Toledo, OH 43606 USA
来源：
SEMINARS IN VASCULAR SURGERY | 2015年 / 28卷 / 01期
关键词：
SMOOTH-MUSCLE-CELLS; COLLAGEN TYPE-III; VARICOSE-VEINS; LEG ULCER; OUTFLOW OBSTRUCTION; GENERAL-POPULATION; SUPERFICIAL VEINS; C677T MUTATION; INSUFFICIENCY; DISEASE;
D O I：
10.1053/j.semvascsurg.2015.07.003
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The underlying pathophysiology of venous ulceration is venous hypertension, which initiates a complex cascade of cellular humeral events that are then magnified by genetic factors. Hemodynamic abnormalities are features of primary and secondary chronic venous diseases that lead to disease progression. Through a sequence of events, some patients develop venous leg ulcers, if the process is not interrupted. The exact science of the pathophysiology of the progression of chronic venous disease to venous leg ulcers is still in its infancy, but the framework for future study has been established. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：6 / 14
页数：9
相关论文
共 67 条
[1]   Valvular density alone cannot account for sites of chronic venous insufficiency and ulceration in the lower extremity [J].
Aharinejad, S ;
Nedwed, S ;
Michlits, W ;
Dunn, R ;
Abraham, D ;
Vernadakis, A ;
Marks, SC .
MICROCIRCULATION, 2001, 8 (05) :347-354
[2]   The microvenous valvular anatomy of the human dorsal thoracic fascia [J].
Aharinejad, S ;
Dunn, RM ;
Fudem, GM ;
Vernadakis, A ;
Bock, P ;
Firbas, W ;
Marks, SC .
PLASTIC AND RECONSTRUCTIVE SURGERY, 1997, 99 (01) :78-86
[3]   A Review of Familial, Genetic, and Congenital Aspects of Primary Varicose Vein Disease [J].
Anwar, Muzaffar A. ;
Georgiadis, Kyrillos Adesina ;
Shalhoub, Joseph ;
Lim, Chung S. ;
Gohel, Manjit S. ;
Davies, Alun H. .
CIRCULATION-CARDIOVASCULAR GENETICS, 2012, 5 (04) :460-466
[4]   Inflammatory cytokine levels in chronic venous insufficiency ulcer tissue before and after compression therapy [J].
Beidler, Stephanie K. ;
Douillet, Christelle D. ;
Berndt, Daniel F. ;
Keagy, Blair A. ;
Rich, Prestort B. ;
Marston, William A. .
JOURNAL OF VASCULAR SURGERY, 2009, 49 (04) :1013-1020
[5]   Mechanisms of disease:: Chronic venous disease [J].
Bergan, John J. ;
Schmid-Schoenbein, Geert W. ;
Smith, Philip D. Coleridge ;
Nicolaides, Andrew N. ;
Boisseau, Michel R. ;
Eklof, Bo .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (05) :488-498
[6]   Oxygen content of blood in patients with varicose veins [J].
Blalock, A .
ARCHIVES OF SURGERY, 1929, 19 (05) :898-905
[7]  
BRAIDE M, 1984, MICROVASC RES, V27, P331, DOI 10.1016/0026-2862(84)90064-5
[8]   ULTRASTRUCTURE OF THE HUMAN DERMAL MICRO-CIRCULATION .4. VALVE-CONTAINING COLLECTING VEINS AT THE DERMAL SUBCUTANEOUS JUNCTION [J].
BRAVERMAN, IM ;
KEHYEN, A .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1983, 81 (05) :438-442
[9]  
BURNAND K, 1976, LANCET, V1, P936
[10]   PERICAPILLARY FIBRIN IN THE ULCER-BEARING SKIN OF THE LEG - THE CAUSE OF LIPODERMATOSCLEROSIS AND VENOUS ULCERATION [J].
BURNAND, KG ;
WHIMSTER, I ;
NAIDOO, A ;
BROWSE, NL .
BMJ-BRITISH MEDICAL JOURNAL, 1982, 285 (6348) :1071-1072
1234567