Tubo-ovarian dysplasia in relationship with ovulation induction in rats

被引：12
作者：
Lacoste, Claude Regis [1 ]
Clemenson, Alix [2 ]
Lima, Suzanne [1 ]
Lecointre, Romain [3 ]
Peoc'h, Michel [2 ]
Chene, Gautier [1 ]
机构：
[1] CHU Nord, Dept Obstet Gynecol & Reprod Med, St Etienne, France
[2] CHU Nord, Dept Histopathol, St Etienne, France
[3] Lyon Sud Hosp, Dept Pharm Clin Oncol, Lyon, France
来源：
FERTILITY AND STERILITY | 2013年 / 99卷 / 06期
关键词：
Ki67; expression; ovarian dysplasia; ovulation stimulation; p53; OVARIAN EPITHELIAL DYSPLASIA; PROPHYLACTIC OOPHORECTOMY; CONTRALATERAL OVARY; SURFACE EPITHELIUM; CANCER INCIDENCE; FERTILITY DRUGS; FALLOPIAN-TUBES; TUBAL FIMBRIA; INFERTILITY; WOMEN;
D O I：
10.1016/j.fertnstert.2013.01.127
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To assess tubo-ovarian dysplasia via morphologic and immunohistochemical study of rats exposed to ovulation stimulation protocols. Design: Animal experimental study. Setting: Academic research hospital. Animal(s): 72 female Wistar rats divided into three groups. Intervention(s): Stimulation protocols using follicle-stimulating hormone (FSH) or clomiphene citrate for 3, 6, or 12 cycles, after which the animals were killed. Main Outcome Measure(s): Ovarian and tubal dysplasia score and immunohistochemical assessment using p53 and Ki67. Result(s): The ovarian dysplasia score was statistically significantly higher after 12 stimulation cycles in the groups receiving FSH (group B) or clomiphene citrate (group C) compared with control (group A). The tubal dysplasia score was statistically significantly increased after only three stimulation cycles in groups B and C. The Ki67 proliferation marker was statistically significantly expressed in the ovaries from group C, and in the fallopian tubes from groups B and C. P53 was constantly low in all three groups. Conclusion(s): Ovulation stimulation may induce tubal and ovarian histopathologic and immunohistochemical abnormalities with a dose effect. The role of the fallopian tubes and their interaction with the ovaries require further study. (c) 2013 by American Society for Reproductive Medicine.
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收藏
页码：1768 / +
页数：14
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