Oral alitretinoin: a review of the clinical pharmacokinetics and pharmacodynamics

被引：0

作者：

Schmitt-Hoffmann, A. H. ^{[1
]}

Roos, B. ^{[1
]}

Schoetzau, A. ^{[2
]}

Leese, P. T. ^{[3
]}

Meyer, I. ^{[4
]}

van de Wetering, J. ^{[5
]}

Kovacs, P. ^{[6
]}

机构：

[1] Basilea Pharmaceut Int Ltd, Basel, Switzerland

[2] Schoetzau & Simmen, Basel, Switzerland

[3] Quintiles Phase I Serv, Lenexa, KS USA

[4] Quintiles GmbH, Freiburg, Germany

[5] PRA Int, Groningen, Netherlands

[6] Med & Hlth Sci Ctr, Debrecen, Hungary

来源：

EXPERT REVIEW OF CLINICAL PHARMACOLOGY | 2012年 / 5卷 / 04期

关键词：

alitretinoin; chronic hand eczema; combined oral contraceptives; food; interactions; pharmacokinetics;

D O I：

10.1586/ECP.12.26

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Alitretinoin is an endogenous retinoid related to vitamin A. Studies have shown that oral alitretinoin is effective and well tolerated in the treatment of severe chronic hand eczema. This review summarizes the clinical pharmacokinetic and pharmacodynamic data from a number of studies involving alitretinoin. These include the effect of food on the pharmacokinetics of alitretinoin, interactions between alitretinoin and ketoconazole, simvastatin or cyclosporin A, the effect of alitretinoin on the pharmacokinetics of a combined oral contraceptive, alitretinoin in seminal fluid after repeated dosing, and the pharmacokinetics of alitretinoin and its metabolites in a clinical setting.

引用

页码：373 / 388

页数：16

共 26 条

[1] Redefining treatment options in chronic hand eczema (CHE) [J].

Bissonnette, Robert ;

Diepgen, Thomas L. ;

Elsner, Peter ;

English, John ;

Graham-Brown, Robin ;

Homey, Bernhard ;

Luger, Thomas ;

Lynde, Charles ;

Maares, Juergen ;

Maibach, Howard I. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2010, 24 :1-20

[2] EFFECT OF MEALS ON THE KINETICS OF ETRETINATE [J].

COLBURN, WA ;

GIBSON, DM ;

RODRIGUEZ, LC ;

BUGGE, CJL ;

BLUMENTHAL, HP .

JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 25 (08) :583-589

[3] FOOD INCREASES THE BIOAVAILABILITY OF ISOTRETINOIN [J].

COLBURN, WA ;

GIBSON, DM ;

WIENS, RE ;

HANIGAN, JJ .

JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 23 (11-1) :534-539

[4] Hand eczema classification: a cross-sectional, multicentre study of the aetiology and morphology of hand eczema [J].

Diepgen, T. L. ;

Andersen, K. E. ;

Brandao, F. M. ;

Bruze, M. ;

Bruynzeel, D. P. ;

Frosch, P. ;

Goncalo, M. ;

Goossens, A. ;

Le Coz, C. J. ;

Rustemeyer, T. ;

White, I. R. ;

Agner, T. .

BRITISH JOURNAL OF DERMATOLOGY, 2009, 160 (02) :353-358

[5]

DOOSE DR, 1992, J CLIN PHARMACOL, V32, P1089

[6]

Freedberg IM., 1999, FITZPATRICKS DERMATO, V5

[7] Oral 13-cis retinoic acid is superior to 9-cis retinoic acid in sebosuppression in human beings [J].

Geiger, JM ;

Hommel, L ;

Harms, M ;

Saurat, JH .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1996, 34 (03) :513-515

[8] Oral retinoids - Efficacy and toxicity in psoriasis [J].

Gollnick, HPM .

BRITISH JOURNAL OF DERMATOLOGY, 1996, 135 :6-17

[9] INFLUENCE OF FOOD ON THE BIOAVAILABILITY OF RO-15-0778 IN HUMANS [J].

HOLAZO, AA ;

PINILI, EE ;

DEGRAZIA, FT ;

PATEL, IH .

PHARMACEUTICAL RESEARCH, 1990, 7 (07) :777-779

[10]

JONES H, 1980, LANCET, V2, P1048

← 1 2 3 →