Alstoniaphyllines A-C, Unusual Nitrogenous Derivatives from the Bark of Alstonia macrophylla

被引：30

作者：

Cheenpracha, Sarot ^{[1
]}

Ritthiwigrom, Thunwadee ^{[2
]}

Laphookhieo, Surat ^{[3
]}

机构：

[1] Univ Phayao, Sch Sci, Muang 56000, Phayao, Thailand

[2] Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand

[3] Mae Fah Luang Univ, Sch Sci, Nat Prod Res Lab, Muang 57100, Chiang Rai, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 04期

关键词：

MONOTERPENOID INDOLE ALKALOIDS; CARBAZOLE ALKALOIDS; EXTRACTS;

D O I：

10.1021/np3006937

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation of an alkaloidal extract of Alstonia macrophylla bark led to the isolation and identification of two new nitrogenous derivatives, alstoniaphyllines A (1) and B (2), a new indole alkaloid, alstoniaphylline C (4), and eight known alkaloids (3, 5-11). Alstonisine (9) exhibited antiplasmodial activity against Plasmodium falciparum, with an IC50 of 7.6 mu M.

引用

页码：723 / 726

页数：4

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