Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-α production in murine macrophages

被引：7
|
作者：
Manjeet, R [1 ]
Ghosh, B [1 ]
机构：
[1] Ctr Biochem Technol, Mol Immunol & Immunogenet Lab, Delhi 110007, India
来源：
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1999年 / 21卷 / 07期
关键词：
tumor necrosis factor-alpha (TNF-alpha); nitric oxide (NO); quercetin; Rhododendron cinnabarium; bacterial lipopolysaccharide (LPS);
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
High amounts of nitric oxide and TNF-alpha generated by activated macrophages induce several pathophysiological conditions during acute and chronic inflammation. Identification of new pharmacological reagents that can prevent TNF-alpha and/or NO overproduction is of considerable medical interest. In this report we provide evidence that the overproduction of TNF-alpha and NO by LPS stimulated macrophages can be markedly inhibited by quercetin, a major active component of plant Rhododendron cinnabarium. (C) 1999 International Society for Immunopharmacology. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：435 / 443
页数：9
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