Achievement of Tolerance Induction to Prevent Acute Graft-vs.-Host Disease

被引：25

作者：

Thangavelu, Govindarajan ^{[1
]}

Blazar, Bruce R. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Pediat, Masonic Canc Ctr, Div Blood & Marrow Transplantat, Minneapolis, MN 55455 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

graft-vs.-host disease; immune tolerance; alpha-1; antitrypsin; allogeneic hematopoietic stem cell transplantation; T regulatory cells; REGULATORY T-CELLS; BONE-MARROW-TRANSPLANTATION; MINOR HISTOCOMPATIBILITY BARRIERS; CHAIN FATTY-ACIDS; ACUTE GVHD; IN-VIVO; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE; ANTITHYMOCYTE GLOBULIN; VERSUS-LEUKEMIA; GUT MICROBIOTA;

D O I：

10.3389/fimmu.2019.00309

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acute graft-vs.-host disease (GVHD) limits the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT), a main therapy to treat various hematological disorders. Despite rapid progress in understanding GVHD pathogenesis, broad immunosuppressive agents are most often used to prevent and remain the first line of therapy to treat GVHD. Strategies enhancing immune tolerance in allo-HSCT would permit reductions in immunosuppressant use and their associated undesirable side effects. In this review, we discuss the mechanisms responsible for GVHD and advancement in strategies to achieve immune balance and tolerance thereby avoiding GVHD and its complications.

引用

页数：17

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