Inulin, a flexible oligosaccharide. II: Review of its pharmaceutical applications

被引:126
作者
Mensink, Maarten A. [1 ]
Frijlink, Henderik W. [1 ]
Maarschalk, Kees van der Voort [1 ,2 ]
Hinrichs, Wouter L. J. [1 ]
机构
[1] Univ Groningen, Dept Pharmaceut Technol & Biopharm, NL-9713 AV Groningen, Netherlands
[2] Coit Purac, Proc Technol, NL-4200 AA Gorinchem, Netherlands
关键词
Fructan; Anhydrobiosis; Vaccines; Stabilizer; Formulation; Excipient; SUBUNIT VACCINE POWDER; DELTA INULIN; CONTROLLED-RELEASE; METHACRYLATED INULIN; SOLID DISPERSIONS; INFLUENZA VACCINE; DIETARY FIBER; SUGAR GLASSES; FORMULATION; DELIVERY;
D O I
10.1016/j.carbpol.2015.08.022
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Inulin is a flexible oligosaccharide which has been used primarily in food for decades. Recently new applications in the pharmaceutical arena were described. In a previous review (Mensink et al. (2015). Carbohydrate Polymers, 130, 405) we described the physicochemical characteristics of inulin, characteristics which make inulin a highly versatile substance. Here, we review its pharmaceutical applications. Applications of inulin that are addressed are stabilization of proteins, modified drug delivery (dissolution rate enhancement and drug targeting), and lastly physiological and disease-modifying effects of inulin. Further uses of inulin include colon specific drug administration and stabilizing and adjuvating vaccine formulations. Overall, the uses of inulin in the pharmaceutical area are very diverse and research is still continuing, particularly with chemically modified inulins. It is therefore likely that even more applications will be found for this flexible oligosaccharide. (C) 2015 The Authors. Published by Elsevier Ltd.
引用
收藏
页码:418 / 428
页数:11
相关论文
共 106 条
[1]   Protective effects of prebiotics inulin and lactulose from cytotoxicity and genotoxicity in human colon adenocarcinoma cells [J].
Adebola, Oluwakemi ;
Corcoran, Olivia ;
Morgan, Winston A. .
FOOD RESEARCH INTERNATIONAL, 2013, 52 (01) :269-274
[2]   Permeability and swelling studies on free films containing inulin in combination with different polymethacrylates aimed for colonic drug delivery [J].
Akhgari, A. ;
Farahmand, F. ;
Garekani, H. Afrasiabi ;
Sadeghi, F. ;
Vandamme, T. F. .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2006, 28 (04) :307-314
[3]   Rational design of an influenza subunit vaccine powder with sugar glass technology: Preventing conformational changes of haemagglutinin during freezing and freeze-drying [J].
Amorij, J.-P. ;
Meulenaar, J. ;
Hinrichs, W. L. J. ;
Stegmann, T. ;
Huckriede, A. ;
Coenen, F. ;
Frijlink, H. W. .
VACCINE, 2007, 25 (35) :6447-6457
[4]   Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice [J].
Amorij, J-P. ;
Saluja, V. ;
Petersen, A. H. ;
Hinrichs, W. L. J. ;
Huckriede, A. ;
Frijlink, H. W. .
VACCINE, 2007, 25 (52) :8707-8717
[5]   Inulin-type fructans: A review on different aspects of biochemical and pharmaceutical technology [J].
Apolinario, Alexsandra Conceicao ;
Goulart de Lima Damasceno, Bolivar Ponciano ;
de Macedo Beltrao, Napoleao Esberard ;
Pessoa, Adalberto ;
Converti, Attilio ;
da Silva, Jose Alexsandro .
CARBOHYDRATE POLYMERS, 2014, 101 :368-378
[6]   Development of a dried influenza whole inactivated virus vaccine for pulmonary immunization [J].
Audouy, Sandrine A. L. ;
van der Schaaf, Gieta ;
Hinrichs, Wouter L. J. ;
Frijlink, Henderik W. ;
Wilschut, Jan ;
Huckriede, Anke .
VACCINE, 2011, 29 (26) :4345-4352
[7]   A systematic study on lyophilization process of polymersomes for long-term storage using doxorubicin-loaded (PEG)3-PLA nanopolymersomes [J].
Ayen, Wubeante Yenet ;
Kumar, Neeraj .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 46 (05) :405-414
[8]  
Barclay T., 2010, Journal of Excipients and Food Chemicals, V1, P27
[9]   Differential scanning calorimetry study on drug release from an inulin-based hydrogel and its interaction with a biomembrane model: pH and loading effect [J].
Castelli, Francesco ;
Sarpietro, Maria Grazia ;
Micieli, Dorotea ;
Ottimo, Sara ;
Pitarresi, Giovanna ;
Tripodo, Giuseppe ;
Carlisi, Bianca ;
Giammona, Gaetano .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 35 (1-2) :76-85
[10]   Investigation on formulation and preparation of adenovirus encoding human endostatin lyophilized powders [J].
Chen, Shuangning ;
Guo, Dongwei ;
Guo, Baisong ;
Liu, Jieying ;
Shen, Yuanyuan ;
Xu, Xiaofen ;
Huang, Wenlin ;
Guo, Shengrong .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2012, 427 (02) :145-152