Supportive Family Environments, Genes That Confer Sensitivity, and Allostatic Load Among Rural African American Emerging Adults: A Prospective Analysis

被引：34

作者：

Brody, Gene H. ^{[1
]}

Yu, Tianyi ^{[1
]}

Chen, Yi-fu ^{[1
]}

Kogan, Steven M. ^{[1
,2
]}

Evans, Gary W. ^{[3
,4
]}

Windle, Michael ^{[5
]}

Gerrard, Meg ^{[6
]}

Gibbons, Frederick X. ^{[7
]}

Simons, Ronald L. ^{[8
]}

Philibert, Robert A. ^{[9
]}

机构：

[1] Univ Georgia, Ctr Family Res, Athens, GA 30602 USA

[2] Univ Georgia, Dept Child & Family Dev, Athens, GA 30602 USA

[3] Cornell Univ, Dept Design & Environm Anal, Ithaca, NY 14853 USA

[4] Cornell Univ, Dept Human Dev, Ithaca, NY 14853 USA

[5] Emory Univ, Dept Behav Sci & Hlth Educ, Atlanta, GA 30322 USA

[6] Dartmouth Coll, Dept Psychiat, Hanover, NH 03755 USA

[7] Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA

[8] Univ Georgia, Dept Sociol, Athens, GA 30602 USA

[9] Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA

来源：

JOURNAL OF FAMILY PSYCHOLOGY | 2013年 / 27卷 / 01期

关键词：

allostatic load; African American; environment; family; genetics; DIFFERENTIAL SUSCEPTIBILITY; STRESS; POLYMORPHISM; CONFLICT; BEHAVIOR; HEALTH; RISK; REACTIVITY; PHENOTYPE; CORTISOL;

D O I：

10.1037/a0027829

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

The purpose of this study was to investigate interactions between exposure to supportive family environments and genetic characteristics, which were hypothesized to forecast variations in allostatic load (AL) in a representative sample of 315 rural African American youths. Data on family environments were gathered when youths were 11-13, and genetic data were collected when they were 16, years of age. Data on AL were obtained at the beginning of emerging adulthood, age 19 years. The data analyses revealed that, as predicted, emerging adults exposed to less supportive family environments across preadolescence manifested higher levels of AL when they carried the short (s) allele at the 5-HTTLPR and an allele of DRD4 with seven or more repeats. This is an E(family environment) x G(5-HTTLPR status) x G(DRD4 status) interaction. These data suggest that African American youths carrying genes that confer sensitivity who are exposed to less supportive family environments may be at greater risk for adverse physical health consequences that AL presages.

引用

页码：22 / 29

页数：8

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[31] RELIABLE MEASURES OF BEHAVIORALLY-EVOKED CARDIOVASCULAR REACTIVITY FROM A PC-BASED TEST BATTERY - RESULTS FROM STUDENT AND COMMUNITY SAMPLES [J].