Breaking the ice: urine proteomics of medullary sponge kidney disease

被引：4

作者：

Chutipongtanate, Somchai ^{[1
]}

机构：

[1] Mahidol Univ, Fac Med, Ramathibodi Hosp, Dept Pediat,Pediat Translat Res Unit, Salaya, Thailand

来源：

KIDNEY INTERNATIONAL | 2017年 / 91卷 / 02期

关键词：

biomarker; medullary sponge kidney; renal stone; urine; IDENTIFICATION;

D O I：

10.1016/j.kint.2016.10.032

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinically compatible enzyme-linked immunosorbent assay. The neglected issue of stone pathogenesis was also evidenced. This commentary discusses several considerations in biomarker validation, and how urinary proteomics breaks new ground in MSK research.

引用

收藏

页码：281 / 283

页数：4

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