Effects of a hypercaloric diet on β-cell responsivity in lean healthy men

被引:14
作者
Brands, Myrte [1 ,2 ]
Swat, Maciej [3 ,4 ]
Lammers, Nicolette M. [1 ,2 ]
Sauerwein, Hans P. [1 ,2 ]
Endert, Erik [5 ]
Ackermans, Mariette T. [5 ]
Verhoeven, Arthur J. [3 ]
Serlie, Mireille J. [1 ,2 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Endocrinol, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Metab, NL-1105 AZ Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1105 AZ Amsterdam, Netherlands
[4] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Physiol, Amsterdam, Netherlands
[5] Univ Amsterdam, Acad Med Ctr, Dept Clin Chem, Lab Endocrinol, NL-1105 AZ Amsterdam, Netherlands
关键词
HEPATIC INSULIN EXTRACTION; C-PEPTIDE; GLUCOSE-HOMEOSTASIS; PLASMA-GLUCOSE; CLEARANCE; RESISTANCE; SECRETION; HYPERINSULINEMIA; SENSITIVITY; OBESITY;
D O I
10.1111/j.1365-2265.2012.04364.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective Insulin resistance and hyperinsulinaemia precede the onset of obesity-induced DM2. The early adaptation of the beta-cell during the initial phase of overfeeding and weight gain has only been partly elucidated. We studied the early changes in insulin clearance and beta-cell responsivity during a positive and negative energy balance in lean healthy men. Design We studied in nine healthy lean men [age, 37 (2743) years; BMI, 23.6 (20.625.6) kg/m2] insulin sensitivity, insulin clearance, insulin secretion and static and dynamic beta-cell responsivity at baseline and after the hypercaloric and subsequent hypocaloric diet. Results Participants gained 7 [5.17.6]% of their initial body weight on the hypercaloric diet. Compared to baseline, insulin sensitivity and insulin clearance decreased, while glucose-stimulated insulin secretion was higher. The GLP-1 response to oral glucose did not change. The dynamic beta-cell responsivity index increased but the basal and static responsivity indexes did not change. Total and static disposition indexes (DIs) in the hypercaloric state showed a trend towards a decrease. During the hypocaloric diet, insulin sensitivity, glucose-stimulated insulin secretion and insulin clearance returned to baseline. The responsivity and the DIs were not different in the hypocaloric phase compared to baseline. Conclusion A positive energy balance resulting in weight gain in lean men induces hyperinsulinaemia, which is explained by a combined effect on insulin clearance and insulin secretion. Increased insulin secretion was related to insulin resistance-induced higher glucose concentrations but also to increased dynamic beta-cell responsivity. Glucose sensitivity of the beta-cell did not change. These early adaptations are completely reversible during a negative energy balance after loss of the gained weight.
引用
收藏
页码:217 / 225
页数:9
相关论文
共 40 条
  • [1] Early responses of insulin signaling to high-carbohydrate and high-fat overfeeding
    Adochio, Rebecca L.
    Leitner, J. Wayne
    Gray, Karen
    Draznin, Boris
    Cornier, Marc-Andre
    [J]. NUTRITION & METABOLISM, 2009, 6
  • [2] [Anonymous], 2006, HLTH COUNC NETH PUBL
  • [3] Balbo SL, 2002, DIABETES METAB, V28, pS13
  • [4] Orchestration of glucose homeostasis - From a small acorn to the California oak
    Bergman, Richard N.
    [J]. DIABETES, 2007, 56 (06) : 1489 - 1501
  • [5] BONORA E, 1984, J CLIN ENDOCR METAB, V59, P1121, DOI 10.1210/jcem-59-6-1121
  • [6] Oral glucose tolerance test minimal model indexes of β-cell function and insulin sensitivity
    Breda, E
    Cavaghan, MK
    Toffolo, G
    Polonsky, KS
    Cobelli, C
    [J]. DIABETES, 2001, 50 (01) : 150 - 158
  • [7] Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men
    Brons, Charlotte
    Jensen, Christine B.
    Storgaard, Heidi
    Hiscock, Natalie J.
    White, Andrew
    Appel, Julie S.
    Jacobsen, Stine
    Nilsson, Emma
    Larsen, Claus M.
    Astrup, Arne
    Quistorff, Bjorn
    Vaag, Allan
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (10): : 2387 - 2397
  • [8] Incretin effect potentiates β-cell responsivity to glucose as well as to its rate of change:: OGTT and matched intravenous study
    Campioni, Marco
    Toffolo, Gianna
    Shuster, Lynne T.
    Service, F. John
    Rizza, Robert A.
    Cobelli, Claudio
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 292 (01): : E54 - E60
  • [9] Assessment of β-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests
    Cobelli, Claudio
    Toffolo, Gianna Maria
    Dalla Man, Chiara
    Campioni, Marco
    Denti, Paolo
    Caumo, Andrea
    Butler, Peter
    Rizza, Robert
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (01): : E1 - E15
  • [10] Insulin sensitivity by oral glucose minimal models: validation against clamp
    Dalla Man, C
    Yarasheski, KE
    Caumo, A
    Robertson, H
    Toffolo, G
    Polonsky, KS
    Cobelli, C
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2005, 289 (06): : E954 - E959