Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population

被引：29

作者：

Chang, Tian-Jong ^{[1
,2
]}

Zheng, Cai-Mei ^{[3
,4
,5
]}

Wu, Mei-Yi ^{[3
,4
]}

Chen, Tzu-Ting ^{[6
]}

Wu, Yun-Chun ^{[6
]}

Wu, Yi-Lien ^{[7
,8
]}

Lin, Hsin-Ting ^{[9
]}

Zheng, Jing-Quan ^{[1
,10
]}

Chu, Nain-Feng ^{[11
,12
]}

Lin, Yu-Me ^{[13
]}

Su, Sui-Lung ^{[11
]}

Lu, Kuo-Cheng ^{[14
]}

Chen, Jin-Shuen ^{[15
]}

Sung, Fung-Chang ^{[16
]}

Lee, Chien-Te ^{[17
]}

Yang, Yu ^{[18
]}

Hwang, Shang-Jyh ^{[19
]}

Wang, Ming-Cheng ^{[20
]}

Hsu, Yung-Ho ^{[3
,4
]}

Chiou, Hung-Yi ^{[13
]}

Kao, Senyeong ^{[1
,11
]}

Lin, Yuh-Feng ^{[1
,3
,4
,5
,8
,15
,18
]}

机构：

[1] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan

[2] Taipei Med Univ, Shuang Ho Hosp, Performance Appraisal Sect, Secretary Off, Taipei, Taiwan

[3] Taipei Med Univ, Sch Med, Dept Internal Med, Coll Med, Taipei, Taiwan

[4] Taipei Med Univ, Shuang Ho Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan

[5] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan

[6] Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan

[7] Taipei Med Univ, Sch Nursing, Coll Nursing, Taipei, Taiwan

[8] Kidney Dis Prevent Fdn, Taipei, Taiwan

[9] Natl Def Med Ctr, Dept Ophthalmol, Tri Serv Gen Hosp, Taipei, Taiwan

[10] Taipei Med Univ, Shuang Ho Hosp, Dept Crit Care Med, Taipei, Taiwan

[11] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan

[12] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung, Taiwan

[13] Taipei Med Univ, Coll Publ Hlth & Nutr, Sch Publ Hlth, Taipei, Taiwan

[14] Fu Jen Catholic Univ, Sch Med, Fu Jen Catholic Univ Hosp, Dept Med,Div Nephrol, Taipei, Taiwan

[15] Natl Def Med Ctr, Tri Serv Gen Hosp, Dept Med, 15Divis Nephrol, Taipei, Taiwan

[16] China Med Univ, Grad Inst Clin Med Sci, Sch Publ Hlth, Taichung, Taiwan

[17] Chang Gung Med Univ, Kaohsiung Chang Gung Mem Hosp, Div Nephrol, Kaohsiung, Taiwan

[18] Changhua Christian Hosp, Div Nephrol, Changhua, Taiwan

[19] Kaohsiung Med Univ Hosp, Dept Med, Div Nephrol, Kaohsiung, Taiwan

[20] Cheng Kung Univ, Dept Internal Med, Div Nephrol, Med Ctr, Tainan, Taiwan

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

关键词：

METABOLIC SYNDROME; CARDIOMETABOLIC HEALTH; WAIST CIRCUMFERENCE; FAT DISTRIBUTION; ADIPOSE-TISSUE; ALL-CAUSE; OBESITY; ASSOCIATION; RISK; MORTALITY;

D O I：

10.1038/s41598-018-24757-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008-2013) and National Health Insurance Research Database (2001-2013). A total of 7357 patients with CKD aged 20-85 years from 14 hospitals were included in the study. A higher male sex, diabetes mellitus (DM) and hypertension were noted among overweight and obese CKD patients, while more cancer prevalence was noted among underweight CKD patients. Charlson comorbidity index was significantly higher and correlated with BMI among late CKD patients. Patients with BMI < 18.5 kg/m(2) exhibited non-significantly higher events of eGFR decline events in both early and late CKD stages than other BMI groups. BMI alone is not a determinant of CKD progression among our Taiwanese CKD patients. Obesity should be re-defined and body weight manipulation should be individualized in CKD patients.

引用

页数：12

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