Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination

被引：4

作者：

Cabodevilla, Jaione Saez ^{[1
,2
]}

Volbeda, Anne ^{[3
]}

Hamelin, Olivier ^{[1
]}

Latour, Jean-Marc ^{[1
]}

Gigarel, Oceane ^{[3
]}

Clemancey, Martin ^{[1
]}

Darnault, Claudine ^{[3
]}

Reichmann, Debora ^{[1
,4
]}

Amara, Patricia ^{[3
]}

Fontecilla-Camps, Juan C. ^{[3
]}

de Choudens, Sandrine Ollagnier ^{[1
]}

机构：

[1] Univ Grenoble Alpes, CNRS, CEA, BIG LCBM,UMR5249, F-38000 Grenoble, France

[2] Univ Grenoble Alpes, ICMG FR 2607, Departement Pharmacochim Mol, CNRS, F-38041 Grenoble, France

[3] Univ Grenoble Alpes, CNRS, Metalloprot, CEA,IBS, F-38000 Grenoble, France

[4] Wachholtzstr 2, D-38106 Braunschweig, Germany

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 26期

关键词：

ESCHERICHIA-COLI; PYROCOCCUS-HORIKOSHII; CRYSTAL-STRUCTURES; BIOSYNTHESIS; SYNTHETASE; SUBSTRATE; BINDING; COMPLEX; ENZYME;

D O I：

10.1039/c8cc09023h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the first inhibitor of NadA. Using multi-disciplinary approaches we have investigated their action mechanism and discovered additional specific inhibitors of this enzyme.

引用

收藏

页码：3725 / 3728

页数：4

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