Sunlight and skin cancer: Inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens

被引：175
作者：
Ananthaswamy, HN
Loughlin, SM
Cox, P
Evans, RL
Ullrich, SE
Kripke, ML
机构：
[1] Department of Immunology, Univ. Texas M.D. Anderson Cancer C., Box 178, Houston, TX 77030
来源：
NATURE MEDICINE | 1997年 / 3卷 / 05期
关键词：
D O I：
10.1038/nm0597-510
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
UV-induced mutations in the p53 tumor suppressor gene pray an essential role in skin cancer development. We report here that such mutations cars be detected in UV-irradiated mouse skin months before the gross appearance of skin tumors. Application of SPF-15 sunscreens to mouse skin before each UV irradiation nearly abolished the frequency of p53 mutations. These results indicate that p53 mutation is an early event in UV skin carcinogenesis and that inhibition of this event may serve as an early end point for assessing protective measures against skin cancer development.
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收藏
页码：510 / 514
页数：5
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