Chemoselective Preparation of Unsymmetrical Bis(1,2,3-triazole) Derivatives and Application in Bis(1,2,3-triazole)-Modified Peptidomimetic Synthesis

被引：13

作者：

Niu, Teng-fei ^{[1
]}

Gu, Lin ^{[1
]}

Wang, Liang ^{[2
]}

Yi, Wen-bin ^{[1
]}

Cai, Chun ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Chem Engn Coll, Nanjing 210094, Jiangsu, Peoples R China

[2] Changzhou Univ, Jiangsu Prov Key Lab Fine Petrochem Engn, Changzhou 213164, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 34期

关键词：

Nitrogen heterocycles; Multi-component reactions; Cycloaddition; Click chemistry; Chemoselectivity; Peptidomimetics; ONE-POT; FREE ROUTE; CLICK; LIGATION; OLIGONUCLEOTIDES; TEMPLATE; AZIDES;

D O I：

10.1002/ejoc.201201096

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient chemoselective methodology for the syntheses of unsymmetrical bis(1,2,3-triazole) derivatives has been developed. This protocol utilizes alkynyl-substituted amines as bifunctional linkers to conjoin a copper-free three-component cycloaddition with a copper(I)-catalyzed alkyneazide cycloaddition in a one-pot procedure. In addition, we used this method for the construction of unsymmetrical bis(1,2,3-triazole)-modified peptidomimetics through a combination of multicomponent reactions taking place in a sequential process, which may be utilized in biological applications.

引用

页码：6767 / 6776

页数：10

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