Life is sweet: the cell biology of glycoconjugates

被引：20

作者：

Broussard, Alex C. ^{[1
,2
]}

Boyce, Michael ^{[1
,2
]}

机构：

[1] Duke Univ, Sch Med, Dept Biochem, Durham, NC 27710 USA

[2] Duke Univ, Sch Med, Program Cell & Mol Biol, Durham, NC 27710 USA

来源：

MOLECULAR BIOLOGY OF THE CELL | 2019年 / 30卷 / 05期

基金：

美国国家卫生研究院;

关键词：

PROTEIN GLYCOSYLATION; CONGENITAL DISORDERS; STRUCTURAL BASIS; O-GLCNACYLATION; LARGE GLYCANS; NOTCH; OGT; OLIGOSACCHARIDES; TRAFFICKING; MECHANISMS;

D O I：

10.1091/mbc.E18-04-0247

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells are dazzling in their diversity, both within and across organisms. And yet, throughout this variety runs at least one common thread: sugars. All cells on Earth, in all domains of life, are literally covered in glycans, a term referring to the carbohydrate portion of glycoproteins and glycolipids. In spite of (or, perhaps, because of) their tremendous structural and functional complexity, glycans have historically been underexplored compared with other areas of cell biology. Recently, however, advances in experimental systems and analytical methods have ushered in a renaissance in glycobiology, the study of the biosynthesis, structures, interactions, functions, and evolution of glycans. Today, glycobiology is poised to make major new contributions to cell biology and become more fully integrated into our understanding of cell and organismal physiology.

引用

页码：525 / 529

页数：5

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