Targeting specific bacteria in the oral microbiome

被引:3
作者
Frias-Lopez, Jorge [1 ]
机构
[1] Forsyth Inst, Cambridge, MA 02142 USA
关键词
oral microbiome; antimicrobial peptide; microbial ecology; ANTIMICROBIAL PEPTIDES;
D O I
10.1016/j.tim.2015.07.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A lack of tools that kill selected members of the oral microbiome has hampered the ability to study specific roles of bacteria within bacterial communities. Work by Guo et al. shows the potential of antimicrobial peptides as a tool to assess the role of individual species in the microbial community.
引用
收藏
页码:527 / 528
页数:2
相关论文
共 10 条
[1]   Defining the normal bacterial flora of the oral cavity [J].
Aas, JA ;
Paster, BJ ;
Stokes, LN ;
Olsen, I ;
Dewhirst, FE .
JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (11) :5721-5732
[2]   Next generation of antimicrobial peptides as molecular targeted medicines [J].
Aoki, Wataru ;
Kuroda, Kouichi ;
Ueda, Mitsuyoshi .
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2012, 114 (04) :365-370
[3]   Antimicrobial Peptides - Promising Alternatives to Conventional Antibiotics [J].
Baltzer, Sylvia A. ;
Brown, Melissa H. .
JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, 2011, 20 (04) :228-235
[4]   The Human Oral Microbiome [J].
Dewhirst, Floyd E. ;
Chen, Tuste ;
Izard, Jacques ;
Paster, Bruce J. ;
Tanner, Anne C. R. ;
Yu, Wen-Han ;
Lakshmanan, Abirami ;
Wade, William G. .
JOURNAL OF BACTERIOLOGY, 2010, 192 (19) :5002-5017
[5]  
Eckert R, 2012, Adv Dent Res, V24, P94, DOI 10.1177/0022034512453725
[6]   Targeted killing of Streptococcus mutans by a pheromone-guided "smart" antimicrobial peptide [J].
Eckert, Randal ;
He, Jian ;
Yarbrough, Daniel K. ;
Qi, Fengxia ;
Anderson, Maxwell H. ;
Shi, Wenyuan .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (11) :3651-3657
[7]   Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology [J].
Guo, Lihong ;
McLean, Jeffrey S. ;
Yang, Youngik ;
Eckert, Randal ;
Kaplan, Christopher W. ;
Kyme, Pierre ;
Sheikh, Omid ;
Varnum, Brian ;
Lux, Renate ;
Shi, Wenyuan ;
He, Xuesong .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (24) :7569-7574
[8]   The keystone-pathogen hypothesis [J].
Hajishengallis, George ;
Darveau, Richard P. ;
Curtis, Michael A. .
NATURE REVIEWS MICROBIOLOGY, 2012, 10 (10) :717-725
[9]   Polymicrobial synergy and dysbiosis in inflammatory disease [J].
Lamont, Richard J. ;
Hajishengallis, George .
TRENDS IN MOLECULAR MEDICINE, 2015, 21 (03) :172-183
[10]   Dental plaque as a biofilm and a microbial community – implications for health and disease [J].
Philip D Marsh .
BMC Oral Health, 6 (Suppl 1)