Evolution of Mitochondria as Signaling Organelles

被引：434

作者：

Chandel, Navdeep S. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

CELL METABOLISM | 2015年 / 22卷 / 02期

关键词：

PHYSIOLOGICAL ROLES; MECHANISMS; DYSFUNCTION; METABOLISM;

D O I：

10.1016/j.cmet.2015.05.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondria have primarily been viewed as bioenergetic and biosynthetic organelles that autonomously co-exist within the cell. However, the past two decades have provided evidence that mitochondria function as signaling organelles, constantly communicating with the cytosol to initiate biological events under homeo-static and stress conditions. Thus, the signaling function of the mitochondria may have been selected by nature from the inception of the early eukaryote, as discussed in this essay.

引用

页码：204 / 206

页数：3

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