Polysaccharide from black currant (Ribes nigrum L.) stimulates dendritic cells through TLR4 signaling

被引：2

作者：

Ashigai, Hiroshi ^{[1
]}

Komano, Yuta ^{[1
]}

Wang, Guanying ^{[1
]}

Kawachi, Yasuji ^{[1
]}

Sunaga, Kazuko ^{[2
]}

Yamamoto, Reiko ^{[3
]}

Takata, Ryoji ^{[3
]}

Miyake, Mika ^{[1
]}

Yanai, Takaaki ^{[3
]}

机构：

[1] Kirin Co Ltd, Res Labs Hlth Sci & Food Technol, Tsurumi Ku, 1-17-1 Namamugi, Yokohama, Kanagawa 2308628, Japan

[2] Mercian Corp, Mkt Dept, Nakano Ku, 4-10-2 Nakano, Tokyo 1640001, Japan

[3] Kirin Co Ltd, Res Labs Wine Technol, 4-9-1 Johnan, Fujisawa, Kanagawa 2510057, Japan

来源：

BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH | 2017年 / 36卷 / 04期

关键词：

black currant; polysaccharide; immunostimulation; dendritic cell; LACTIC-ACID BACTERIA; ANTITUMOR-ACTIVITY; MICE; EXPRESSION; INFECTION; BENEFITS; PATHWAY;

D O I：

10.12938/bmfh.16-029

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Black currant (Ribes nigrum) has various beneficial properties for human health. In particular, polysaccharide from black currant was found to be an immunostimulating food ingredient and was reported to have antitumor activity in a mouse model. We named it cassis polysaccharide (CAPS). In a previous study, CAPS administration caused tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) production in vitro and in vivo, but the immunological mechanism of CAPS was not demonstrated. In this study, we revealed the CAPS immunostimulating mechanism in vitro. First, we found that CAPS activated dendritic cells (DCs). Second, we investigated whether it depends on Toll-like receptor 4 (TLR4) and myeloid differentiation primary response (Myd). We concluded that CAPS stimulates DCs through Myd88 depending TLR4 signaling and activates Th1-type cytokine release.

引用

页码：141 / 145

页数：5

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