Four new epoxy taxanes from needles of Taxus cuspidata (Taxaceae)

被引：7

作者：

Shi, QW

Cao, CM

Gu, JS

Kiyota, H ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr Sci, Div Biosci & Biotechnol Future Bioind, Lab Appl Bioorgan Chem,Aoba Ku, Sendai, Miyagi 9818555, Japan

[2] Hebei Med Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, Shijiazhuang 050017, Hebei Province, Peoples R China

[3] Cent Hosp Cangzhou, Dept Pharm, Cangzhou 061028, Hebei Province, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2006年 / 20卷 / 02期

关键词：

11,12-epoxy taxanes; Taxus cuspidata; yew; taxanes; structure elucidation;

D O I：

10.1080/14786410500049426

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Four new epoxy taxoids were isolated from the needles of Taxus cuspidata. Their structures were established as 2 alpha,9 alpha-diacetoxy-5 alpha-cinnamoyloxy-11,12-epoxy-10 beta-hydroxytax-4(20)-en-13-one (1), 2 alpha,10 beta-diacetoxy-5 alpha-cinnamoyloxy-11,12-epoxy-9 alpha-hydroxytax-4(20)-en-13-one (2), 2 alpha,9 alpha-diacetoxy-11,12-epoxy-10 beta,20-dihydroxytax-4-en-13-one (3) and 2 alpha,10 beta-diacetoxy-11,12-epoxy-9 alpha,20-dihydroxytax-4-en-13-one (4) on the basis of spectral analysis including H-1-NMR, C-13-NMR, H-1-H-1- COSY, HSQC, HMBC and HRFABMS. Compounds 3 and 4 are the first example of 11,12-epoxy taxoids with C-4 double bond found in T. cuspidata.

引用

页码：173 / 179

页数：7

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