Application of mode-of-action considerations in human cancer risk assessment

被引：27

作者：

Williams, Gary M. ^{[1
]}

机构：

[1] New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA

来源：

TOXICOLOGY LETTERS | 2008年 / 180卷 / 02期

关键词：

cancer risk assessment; DNA-reactive carcinogen; epigenetic carcinogen; toxicologically; insignificant daily intake; bioindicator;

D O I：

10.1016/j.toxlet.2008.05.021

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The distinction between carcinogens with DNA-reactive and epigenetic modes of action and the application of mode-of-action considerations to risk assessment is reviewed. A bioindicator-based risk assessment strategy is described. This approach involves the use of mechanistic data to establish a "toxicologically insignificant daily intake". (C) 2008 Published by Elsevier Ireland Ltd.

引用

页码：75 / 80

页数：6

共 79 条

[11] Hazard characterisation of chemicals in food and diet: dose response, mechanisms and extrapolation issues [J].

Dybing, E ;

Doe, J ;

Groten, J ;

Kleiner, J ;

O'Brien, J ;

Renwick, AG ;

Schlatter, J ;

Steinberg, P ;

Tritscher, A ;

Walker, R ;

Younes, M .

FOOD AND CHEMICAL TOXICOLOGY, 2002, 40 (2-3) :237-282

[12]

EHRENBERG L, 1973, EVALUATION GENETIC R, P15

[13] EFFECTS OF LOW-DOSES OF N-NITROSOMORPHOLINE ON THE DEVELOPMENT OF EARLY STAGES OF HEPATOCARCINOGENESIS [J].

ENZMANN, H ;

ZERBAN, H ;

KOPPSCHNEIDER, A ;

LOSER, E ;

BANNASCH, P .

CARCINOGENESIS, 1995, 16 (07) :1513-1518

[14]

*EUR FOOD SAF AUTH, 2006, EFA M SUMM REP EFSA

[15]

*EUR FOOD SAF AUTH, 2005, EFSAQ2004020

[16]

FARMER JH, 1980, J ENVIRON PATHOL TOX, V3, P55

[17] Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens [J].

Fukushima, S ;

Kinoshita, A ;

Puatanachokchai, R ;

Kushida, M ;

Wanibuchi, H ;

Morimura, K .

CARCINOGENESIS, 2005, 26 (11) :1835-1845

[18] Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine [J].

Fukushima, S ;

Wanibuchi, H ;

Morimura, K ;

Wei, M ;

Nakae, D ;

Konishi, Y ;

Tsuda, H ;

Uehara, N ;

Imaida, K ;

Shirai, T ;

Tatematsu, M ;

Tsukamoto, T ;

Hirose, M ;

Furukawa, F ;

Wakabayashi, K ;

Totsuka, Y .

JAPANESE JOURNAL OF CANCER RESEARCH, 2002, 93 (10) :1076-1082

[19] Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline:: relevance to risk assessment [J].

Fukushima, S .

CANCER LETTERS, 1999, 143 (02) :157-159

[20] A CARCINOGENIC POTENCY DATABASE OF THE STANDARDIZED RESULTS OF ANIMAL BIOASSAYS [J].

GOLD, LS ;

SAWYER, CB ;

MAGAW, R ;

BACKMAN, GM ;

DEVECIANA, M ;

LEVINSON, R ;

HOOPER, NK ;

HAVENDER, WR ;

BERNSTEIN, L ;

PETO, R ;

PIKE, MC ;

AMES, BN .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1984, 58 (DEC) :9-319

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