Application of mode-of-action considerations in human cancer risk assessment

被引：27

作者：

Williams, Gary M. ^{[1
]}

机构：

[1] New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA

来源：

TOXICOLOGY LETTERS | 2008年 / 180卷 / 02期

关键词：

cancer risk assessment; DNA-reactive carcinogen; epigenetic carcinogen; toxicologically; insignificant daily intake; bioindicator;

D O I：

10.1016/j.toxlet.2008.05.021

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The distinction between carcinogens with DNA-reactive and epigenetic modes of action and the application of mode-of-action considerations to risk assessment is reviewed. A bioindicator-based risk assessment strategy is described. This approach involves the use of mechanistic data to establish a "toxicologically insignificant daily intake". (C) 2008 Published by Elsevier Ireland Ltd.

引用

页码：75 / 80

页数：6

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