Serum anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder presenting as acute eosinophilic encephalomyelitis

被引：6

作者：

Muroishi, Toyoteru ^{[1
]}

Sakai, Kenji ^{[1
]}

Yanase, Daisuke ^{[1
]}

Ikeda, Yoshihisa ^{[1
]}

Machiya, Tomohiko ^{[1
]}

Kato-Motozaki, Yuko ^{[1
,2
]}

Samuraki, Miharu ^{[1
]}

Yamada, Masahito ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Dept Neurol & Neurobiol Aging, 13-1 Takara Machi, Kanazawa, Ishikawa 9208640, Japan

[2] Iou Hosp, Natl Hosp Org, Dept Neurol, Kanazawa, Ishikawa, Japan

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2018年 / 48卷

关键词：

Neuromyelitis optica spectrum disorder; Eosinophil; Encephalomyelitis; Anti-aquaporin-4; antibody; Immunoglobulin E; MECHANISMS;

D O I：

10.1016/j.jocn.2017.10.074

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report the case of a 57-year-old man with neuromyelitis optica spectrum disorder (NMOSD) presenting as acute eosinophilic encephalomyelitis. Magnetic resonance imaging revealed central nervous system lesions typical of NMOSD and anti-aquaporin-4 antibodies in the serum were identified; however, eosinophilia was evident in the cerebrospinal fluid (CSF) at the early stage of the disease. The number of eosinophils in the CSF decreased subsequently. Although activation of eosinophils is known to be an important factor in the development of NMOSD lesions, prominent eosinophilia in the CSF at the early stage of the disease has never been reported in patients with NMOSD. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：93 / 94

页数：2

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