Synthesis, characterization, and anticancer activity of ruthenium-pyrazole complexes

被引：34
作者：
David, Solene [1 ]
Perkins, Richard S. [1 ]
Fronczek, Frank R. [2 ]
Kasiri, Sahba [3 ]
Mandal, Subhrangsu S. [3 ]
Srivastava, Radhey S. [1 ]
机构：
[1] Univ Louisiana Lafayette, Dept Chem, Lafayette, LA 70504 USA
[2] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA
[3] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2012年 / 111卷
关键词：
Ruthenium(III)pyrazole complexes; Crystal structure cyclic voltammetry; in vitro cytotoxicity; TRANSITION-METAL-COMPLEXES; A-TYPE COMPLEXES; COORDINATION CHEMISTRY; ANTITUMOR-ACTIVITY; DNA CLEAVAGE; BINDING; CISPLATIN; APOPTOSIS; DRUGS; CYTOTOXICITY;
D O I：
10.1016/j.jinorgbio.2012.02.022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of new water soluble Ru(III) pyrazole complexes mer-[RuCl3(DMSO-S)(pyz)(2)] 1, mer-[RuCl3(DMSO-S) (DMSO-O)(pyz)) 2, mer-[RuCl3(bpy)(dmpyz)] 3, and mer-[RuCl3(DMSO-S)(dmpyz)21 4 (pyz = pyrazole; dmpyz = 3,5-dimethylpyrazole, bpy = 2,2'-bipyridine) have been synthesized and characterized by use of a combination of spectroscopy (IR and UV-visible). X-ray diffraction, and cyclic voltammetry. The molecular X-ray structure of all reported compounds (1-4) revealed distorted octahedral coordination around ruthenium. The cytotoxicity assay on human breast cancer cells (MCF7) demonstrated that compounds 1 and 4 affect cell viability, whereas compounds 2 and 3 do not show appreciable activity. The IC50 values for 1 and 4 lie within the range of 71-32 mu M in MCF7 cells. (C) 2012 Elsevier Inc. All rights reserved.
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页码：33 / 39
页数：7
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