High resistance to oxidative stress in the fungal pathogen Candida glabrata is mediated by a single catalase, Cta1p, and is controlled by the transcription factors Yap1p, Skn7p, Msn2p, and Msn4p

被引：140

作者：

Cuellar-Cruz, Mayra ^{[1
]}

Briones-Martin-del-Campo, Marcela ^{[1
]}

Canas-Villamar, Israel ^{[1
]}

Montalvo-Arredondo, Javier ^{[1
]}

Riego-Ruiz, Lina ^{[1
]}

Castano, Irene ^{[1
]}

De Las Penas, Alejandro ^{[1
]}

机构：

[1] Inst Potosino Invest Cient & Tecnol, Div Mol Biol, San Luis Potosi 78216, Mexico

来源：

EUKARYOTIC CELL | 2008年 / 7卷 / 05期

关键词：

D O I：

10.1128/EC.00011-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We characterized the oxidative stress response of Candida glabrata to better understand the virulence of this fungal pathogen. C. glabrata could withstand higher concentrations of H2O2 than Saccharomyces cerevisiae and even Candida albicans. Stationary-phase cells were extremely resistant to oxidative stress, and this resistance was dependent on the concerted roles of stress-related transcription factors Yap1p, Skn7p, and Msn4p. We showed that growing cells of C. glabrata were able to adapt to high levels of H2O2 and that this adaptive response was dependent on Yap1p and Skn7p and partially on the general stress transcription factors Msn2p and Msn4p. C. glabrata has a single catalase gene, CTA1, which was absolutely required for resistance to H2O2 in vitro. However, in a mouse model of systemic infection, a strain lacking CTA1 showed no effect on virulence.

引用

页码：814 / 825

页数：12

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