Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies

被引：683

作者：

Pearce, Celeste Leigh ^{[1
]}

Templeman, Claire ^{[2
]}

Rossing, Mary Anne ^{[3
]}

Lee, Alice ^{[1
]}

Near, Aimee M. ^{[4
]}

Webb, Penelope M. ^{[5
]}

Nagle, Christina M. ^{[5
]}

Doherty, Jennifer A. ^{[3
]}

Cushing-Haugen, Kara L. ^{[3
]}

Wicklund, Kristine G. ^{[3
]}

Chang-Claude, Jenny ^{[6
]}

Hein, Rebecca ^{[6
,7
]}

Lurie, Galina ^{[8
]}

Wilkens, Lynne R. ^{[8
]}

Carney, Michael E. ^{[8
]}

Goodman, Marc T. ^{[8
]}

Moysich, Kirsten ^{[9
]}

Kjaer, Susanne K. ^{[10
,11
]}

Hogdall, Estrid ^{[10
]}

Jensen, Allan ^{[10
]}

Goode, Ellen L. ^{[12
]}

Fridley, Brooke L. ^{[12
]}

Larson, Melissa C. ^{[12
]}

Schildkraut, Joellen M. ^{[13
]}

Palmieri, Rachel T. ^{[15
]}

Cramer, Daniel W. ^{[16
]}

Terry, Kathryn L. ^{[16
]}

Vitonis, Allison F. ^{[16
]}

Titus, Linda J. ^{[17
,18
]}

Ziogas, Argyrios ^{[19
]}

Brewster, Wendy ^{[20
]}

Anton-Culver, Hoda ^{[19
]}

Gentry-Maharaj, Alexandra ^{[21
]}

Ramus, Susan J. ^{[1
,21
]}

Anderson, A. Rebecca ^{[1
]}

Brueggmann, Doerthe ^{[2
,22
]}

Fasching, Peter A. ^{[23
,24
]}

Gayther, Simon A. ^{[1
,21
]}

Huntsman, David G. ^{[25
,26
]}

Menon, Usha ^{[21
]}

Ness, Roberta B. ^{[27
]}

Pike, Malcolm C. ^{[1
,28
]}

Risch, Harvey ^{[29
]}

Wu, Anna H. ^{[1
]}

Berchuck, Andrew ^{[14
]}

机构：

[1] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA

[2] Univ So Calif, Keck Sch Med, Dept Gynecol, Los Angeles, CA 90033 USA

[3] Fred Hutchinson Canc Res Ctr, Program Epidemiol, Seattle, WA 98104 USA

[4] Georgetown Univ, Med Ctr, Canc Control Program, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA

[5] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

[6] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[7] Univ Cologne, Dept Child & Adolescent Psychiat & Psychotherapy, D-50931 Cologne, Germany

[8] Univ Hawaii, Canc Res Ctr Hawaii, Honolulu, HI 96813 USA

[9] Roswell Pk Canc Inst, Buffalo, NY 14263 USA

[10] Danish Canc Soc, Dept Virus Hormones & Canc, Inst Canc Epidemiol, Copenhagen, Denmark

[11] Univ Copenhagen, Rigshosp, Gynecol Clin, Juliane Marie Ctr, DK-2100 Copenhagen, Denmark

[12] Mayo Clin, Coll Med, Dept Hlth Sci Res, Rochester, MN USA

[13] Duke Univ, Med Ctr, Dept Community & Family Med, Durham, NC 27710 USA

[14] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA

[15] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

[16] Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Boston, MA 02115 USA

[17] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Community & Family Med, Hanover, NH 03756 USA

[18] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Pediat, Hanover, NH 03756 USA

[19] Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92717 USA

[20] Univ N Carolina, Dept Obstet & Gynecol, Ctr Womens Hlth Res, Chapel Hill, NC USA

[21] UCL, Dept Gynaecol Oncol, Elizabeth Garrett Anderson Inst Womens Hlth, London, England

[22] Univ Giessen, Dept Obstet & Gynaecol, Giessen, Germany

[23] Univ Hosp Erlangen, Dept Obstet & Gynaecol, Erlangen, Germany

[24] Univ Calif Los Angeles, David Geffen Sch Med, Div Hematol & Oncol, Los Angeles, CA 90095 USA

[25] Vancouver Gen Hosp, Dept Pathol, Vancouver, BC V5Z 1M9, Canada

[26] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada

[27] Univ Texas Houston, Sch Publ Hlth, Houston, TX USA

[28] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[29] Yale Univ, Dept Epidemiol & Publ Hlth, Sch Publ Hlth, New Haven, CT 06520 USA

来源：

LANCET ONCOLOGY | 2012年 / 13卷 / 04期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

HOSPITAL DISCHARGE DIAGNOSIS; FERTILITY DRUGS; GENES; WOMEN; SUSCEPTIBILITY; PATHOGENESIS; INFLAMMATION; INFERTILITY; CARCINOMA; ORIGIN;

D O I：

10.1016/S1470-2045(11)70404-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear. We undertook an international collaborative study to assess the association between endometriosis and histological subtypes of ovarian cancer. Methods Data from 13 ovarian cancer case-control studies, which were part of the Ovarian Cancer Association Consortium, were pooled and logistic regression analyses were undertaken to assess the association between self-reported endometriosis and risk of ovarian cancer. Analyses of invasive cases were done with respect to histological subtypes, grade, and stage, and analyses of borderline tumours by histological subtype. Age, ethnic origin, study site, parity, and duration of oral contraceptive use were included in all analytical models. Findings 13 226 controls and 7911 women with invasive ovarian cancer were included in this analysis. 818 and 738, respectively, reported a history of endometriosis. 1907 women with borderline ovarian cancer were also included in the analysis, and 168 of these reported a history of endometriosis. Self-reported endometriosis was associated with a significantly increased risk of clear-cell (136 [20 . 2%] of 674 cases vs 818 [6 . 2%] of 13 226 controls, odds ratio 3 . 05, 95% CI 2 . 43-3 . 84, p<0 . 0001), low-grade serous (31 [9 . 2%] of 336 cases, 2 . 11, 1 . 39-3 . 20, p<0 . 0001), and endometrioid invasive ovarian cancers (169 [13 . 9%] of 1220 cases, 2 . 04, 1 . 67-2 . 48, p<0 . 0001). No association was noted between endometriosis and risk of mucinous (31 [6 . 0%] of 516 cases, 1 . 02, 0 . 69-1 . 50, p=0 . 93) or high-grade serous invasive ovarian cancer (261 [7 . 1%] of 3659 cases, 1 . 13, 0 . 97-1 . 32, p=0 . 13), or borderline tumours of either subtype (serous 103 [9 . 0%] of 1140 cases, 1 . 20, 0 . 95-1 . 52, p=0 . 12, and mucinous 65 [8 . 5%] of 767 cases, 1 . 12, 0 . 84-1 . 48, p=0 . 45). Interpretation Clinicians should be aware of the increased risk of specific subtypes of ovarian cancer in women with endometriosis. Future efforts should focus on understanding the mechanisms that might lead to malignant transformation of endometriosis so as to help identify subsets of women at increased risk of ovarian cancer.

引用

页码：385 / 394

页数：10

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