Effects of Intranasal Oxytocin on Pup Deprivation-Evoked Aberrant Maternal Behavior and Hypogalactia in Rat Dams and the Underlying Mechanisms

被引：16

作者：

Liu, Xiao Yu ^{[1
]}

Li, Dongyang ^{[1
]}

Li, Tong ^{[1
]}

Liu, Haitao ^{[1
]}

Cui, Dan ^{[1
]}

Liu, Yang ^{[1
]}

Jia, Shuwei ^{[1
]}

Wang, Xiaoran ^{[1
]}

Jiao, Runsheng ^{[1
]}

Zhu, Hui ^{[1
]}

Zhang, Fengmin ^{[2
]}

Qin, Danian ^{[3
]}

Wang, Yu-Feng ^{[1
]}

机构：

[1] Harbin Med Univ, Sch Basic Med Sci, Dept Physiol, Harbin, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Sch Basic Med Sci, Dept Pathogen, Harbin, Heilongjiang, Peoples R China

[3] Shantou Univ, Med Coll, Dept Physiol, Shantou, Peoples R China

来源：

FRONTIERS IN NEUROSCIENCE | 2019年 / 13卷

基金：

中国国家自然科学基金;

关键词：

pup deprivation; intranasal drug application; lactation; maternal health; oxytocin; MILK EJECTION BURST; NEURONAL-ACTIVITY; MOTHERS; DEPRESSION; LACTATION; VASOPRESSIN; ASTROCYTES; SEPARATION; INITIATION; INFANT;

D O I：

10.3389/fnins.2019.00122

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Oxytocin (OT), a hypothalamic neuropeptide, applied through nasal approach (IAO), could improve maternal health during lactation that is disrupted by mother-baby separation; however, the regulation of IAO effects on maternal behaviors and lactation as well as the underlying mechanisms remain unclear. Using lactating rats, we observed effects of intermittent pup deprivation (PD) with and without IAO on maternal behaviors and lactation as well as the activity of OT neurons in the supraoptic nucleus (SON) and the activity of hypothalamic pituitary-adrenal axis, key factors determining the milk-letdown reflex during lactation and maternal behaviors. The results showed that PD reduced maternal behaviors and lactation efficiency of rat dams as indicated by significantly longer latency to retrieve their pups and low litter's body weight gains during the observation, respectively. In addition, PD caused early involution of the mammary glands. IAO partially improved these changes in rat dams, which was not as significant as IAO effects on control dams. In the SON, PD decreased c-Fos and increased glial fibrillary acidic protein (GFAP) filaments significantly; IAO made PD-evoked c-Fos reduction insignificant while reduced GFAP filament significantly in PD dams. IAO tended to increase the levels of phosphorylated extracellular signal-regulated kinases (pERK) 1/2 in PD dams. Moreover, PD+IAO significantly increased plasma levels of dam adrenocorticotropic hormone and corticosterone but not OT levels. Lastly, PD+IAO tended to increase the level of corticotropin-releasing hormone in the SON. These results indicate that PD disrupts maternal behaviors and lactation by suppressing the activity of hypothalamic OT-secreting system through expansion of astrocytic processes, which are partially reversed by IAO through removing astrocytic inhibition of OT neuronal activity. However, the improving effect of IAO on the maternal health could be compromised by simultaneous activation of hypothalamic pituitary-adrenocortical axis.

引用

页数：11

共 2 条

[1] Intranasal Oxytocin Restores Maternal Behavior and Oxytocin Neuronal Activity in the Supraoptic Nucleus in Rat Dams with Cesarean Delivery
Li, Tong
Jia, Shu-Wei
Hou, Dan
Liu, Xiaoyu
Li, Dongyang
Liu, Yang
Cui, Dan
Wang, Xiaoran
Hou, Chunmei
Brown, Colin H.
Wang, Yu-Feng
NEUROSCIENCE, 2021, 468 : 235 - 246
[2] Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams
McMurray, M. S.
Joyner, P. W.
Middleton, C. W.
Jarrett, T. M.
Elliott, D. L.
Black, M. A.
Hofler, V. E.
Walker, C. H.
Johns, J. M.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 2008, 11 (05): : 398 - 410

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