Enantioselective desymmetrization of prochiral 1,3-dinitropropanes via organocatalytic allylic alkylation

被引：28
作者：
Roy, Soumya Jyoti Singha [1 ]
Mukherjee, Santanu [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 01期
关键词：
BAYLIS-HILLMAN CARBONATES; ONE-POT SYNTHESIS; ANIONIC DOMINO PROCESS; BIFUNCTIONAL ORGANOCATALYSTS; MBH CARBONATES; 3+2 ANNULATION; NITROALKANES; ADDUCTS; CATALYSIS; GAMMA;
D O I：
10.1039/c3cc47645f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An enantioselective desymmetrization of prochiral 1,3-dinitropropanes has been developed which proceeds via enantiogroup differentiating organocatalytic allylic alkylation. Densely functionalized products with two vicinal stereocenters were obtained generally with good to excellent diastereoselectivity (up to >20:1 dr) and superb enantioselectivity (up to >99:1 er).
引用
收藏
页码：121 / 123
页数：3
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