Apparent diffusion coefficient is a prognostic factor of head and neck squamous cell carcinoma treated with radiotherapy

被引：26

作者：

Hatakenaka, Masamitsu ^{[1
]}

Nakamura, Katsumasa ^{[2
]}

Yabuuchi, Hidetake ^{[3
]}

Shioyama, Yoshiyuki ^{[4
]}

Matsuo, Yoshio ^{[2
]}

Kamitani, Takeshi ^{[2
]}

Yonezawa, Masato ^{[2
]}

Yoshiura, Takashi ^{[2
]}

Nakashima, Torahiko ^{[5
]}

Mori, Mitsuru ^{[6
]}

Honda, Hiroshi ^{[2
]}

机构：

[1] Sapporo Med Univ, Sch Med, Dept Diagnost Radiol, Chuo Ku, Sapporo, Hokkaido 0608556, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Fukuoka 812, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Dept Hlth Sci, Fukuoka 812, Japan

[4] Kyushu Univ, Grad Sch Med Sci, Dept Heavy Particle Therapy & Radiat Oncol, Fukuoka 812, Japan

[5] Kyushu Univ, Grad Sch Med Sci, Dept Otorhinolaryngol, Fukuoka 812, Japan

[6] Sapporo Med Univ, Sch Med, Dept Publ Hlth, Chuo Ku, Sapporo, Hokkaido 0608556, Japan

来源：

JAPANESE JOURNAL OF RADIOLOGY | 2014年 / 32卷 / 02期

关键词：

Apparent diffusion coefficient; Bystander effect; Head and neck cancer; Prognosis; Radiotherapy; RADIATION-THERAPY; BRAIN-TUMORS; PREDICTION; CANCER; MAP; BIOMARKER; PERFUSION; EFFICACY; GRADE;

D O I：

10.1007/s11604-013-0272-y

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

To evaluate the correlation between apparent diffusion coefficient (ADC) and prognosis in head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy. We retrospectively studied 41 patients (38 male and 3 female, ages 37-85 years) diagnosed with HNSCC (14 oropharynx, 22 hypopharynx, 4 larynx, 1 oral cavity) and treated with radiotherapy, with radiation dose to gross tumor volume over 60 Gy. The association between age, gender, performance status, tumor location, T stage, N stage, stage, dose, overall treatment time, treatment method, adjuvant therapy, or ADC and prognosis was analyzed using a Cox proportional hazard test. ADC calculated with b-values of 300, 500, 750, and 1,000 s/mm(2) (ADC 300-1,000) alone showed a significant correlation with all of the analyses (p = 0.022 for local control, p = 0.0109 for regional control, p = 0.0041 for disease-free survival, and p = 0.0014 for overall survival). ADC calculated with b-values of 0, 100, and 200 s/mm(2) (ADC 0-200) showed a significant correlation with overall survival (p = 0.0012). N stage showed a significant correlation with regional control (p = 0.0241). Performance status showed significant association with local control (p = 0.0459), disease-free survival (p = 0.023), and overall survival (p = 0.0151), respectively. ADC is an independent predictor of prognosis in HNSCC treated with radiotherapy.

引用

页码：80 / 89

页数：10

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