Human umbilical cord mesenchymal stem cells and the treatment of spinal cord injury

被引：44
作者：
Fu-jiang, Cao [1 ]
Shi-qing, Feng [1 ]
机构：
[1] Tianjin Med Univ, Gen Hosp, Dept Orthopaed, Tianjin 300052, Peoples R China
来源：
CHINESE MEDICAL JOURNAL | 2009年 / 122卷 / 02期
基金：
中国国家自然科学基金;
关键词：
umbilical cord; mesenchymal stem cells; spinal cord injuries; BONE-MARROW; IN-VITRO; DIFFERENTIATION; BLOOD; EXPRESSION; TRANSPLANTATION; WINGLESS; NEURONS;
D O I：
10.3760/cma.j.issn.0366-6999.2009.02.021
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective To review the recent studies about human umbilical cord mesenchymal stem cells (hUCMSCs) and advances in the treatment of spinal cord injury. Datasources Published articles (1983-2007) about hUCMSCs and spinal cord injury were selected using Medline. Study selection Articles selected were relevant to development of mesenchymal stem cells (MSCs) for transplantation in spinal cord injury therapy. Of 258 originally identified articles 51 were selected that specifically addressed the stated purpose. Results Recent work has revealed that hUCMSCs share most of the characteristics with MSCs derived from bone marrow and are more appropriate to transplantation for cell based therapies. Conclusions Human umbilical cord could be regarded as a source of MSCs for experimental and clinical needs. In addition, as a peculiar source of stem cells, hUCMSCs may play an important role in the treatment of spinal cord injury.
引用
收藏
页码：225 / 231
页数：7
相关论文
共 53 条
[1]   Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy [J].
Baksh, D ;
Song, L ;
Tuan, RS .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2004, 8 (03) :301-316
[2]   Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow [J].
Baksh, Dolores ;
Yao, Raphael ;
Tuan, Rocky S. .
STEM CELLS, 2007, 25 (06) :1384-1392
[3]   Mesenchymal stem cells as trophic mediators [J].
Caplan, Arnold I. ;
Dennis, James E. .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2006, 98 (05) :1076-1084
[4]   Mesenchymal progenitor cells in human umbilical cord blood [J].
Erices, A ;
Conget, P ;
Minguell, JJ .
BRITISH JOURNAL OF HAEMATOLOGY, 2000, 109 (01) :235-242
[5]   Expression profiling and functional analysis of Wnt signaling mechanisms in mesenchymal stem cells [J].
Etheridge, SL ;
Spencer, GJ ;
Heath, DJ ;
Genever, PG .
STEM CELLS, 2004, 22 (05) :849-860
[6]   Immunomodulatory functions of mesenchymal stem cells [J].
Frank, MH ;
Sayegh, MH .
LANCET, 2004, 363 (9419) :1411-1412
[7]   Umbilical cord mesenchymal stem cells: Adjuvants for human cell transplantation [J].
Friedman, Robb ;
Betancur, Monica ;
Boissel, Laurent ;
Tuncer, Hande ;
Cetrulo, Curtis ;
Klingemann, Hans .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2007, 13 (12) :1477-1486
[8]   Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: Potential therapeutic application for parkinsonism [J].
Fu, YS ;
Cheng, YC ;
Lin, MYA ;
Cheng, H ;
Chu, PM ;
Chou, SC ;
Shih, YH ;
Ko, MH ;
Sung, MS .
STEM CELLS, 2006, 24 (01) :115-124
[9]   Multilineage differentiation activity by cells isolated from umbilical cord blood: Expression of bone, fat, and neural markers [J].
Goodwin, HS ;
Bicknese, AR ;
Chien, SN ;
Bogucki, BD ;
Oliver, DA ;
Quinn, CO ;
Wall, DA .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2001, 7 (11) :581-588
[10]   CELL-SURFACE ANTIGENS ON HUMAN MARROW-DERIVED MESENCHYMAL CELLS ARE DETECTED BY MONOCLONAL-ANTIBODIES [J].
HAYNESWORTH, SE ;
BABER, MA ;
CAPLAN, AI .
BONE, 1992, 13 (01) :69-80
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