Copper-Catalyzed Etherification of Arene C-H Bonds

被引：180
作者：
Roane, James [1 ]
Daugulis, Olafs [1 ]
机构：
[1] Univ Houston, Dept Chem, Houston, TX 77204 USA
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 22期
关键词：
CARBON-CARBON BONDS; COUPLING REACTIONS; C(SP(2))-H BONDS; PALLADIUM; ARYLATION; C(SP(3))-H; HYDROGEN; FUNCTIONALIZATIONS; OXYGENATIONS; ALKOXYLATION;
D O I：
10.1021/ol402904d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for direct, auxiliary-assisted alkoxylation and phenoxylation of beta-sp(2) C-H bonds of benzoic acid derivatives and gamma-sp(2) C-H bonds of amine derivatives is reported. The reaction employs (CuOH)(2)CO3 catalyst, air as an oxidant, phenol or alcohol coupling partner, DMF, pyridine, or DMPU solvent, and K2CO3, tetramethylguanidine, or K3PO4 base at 70-130 degrees C.
引用
收藏
页码：5842 / 5845
页数：4
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