Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma

被引：7

作者：

Kreipke, Christian W. ^{[1
]}

Rafols, Jose A. ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2009年 / 13卷 / 02期

关键词：

vascular reactivity; calponin; brain trauma; VASCULAR SMOOTH-MUSCLE; PROTEIN-KINASE-C; CEREBRAL-CORTEX MICROVESSELS; ENDOTHELIAL GROWTH-FACTOR; RAT-BRAIN; ACIDIC CALPONIN; SUBARACHNOID HEMORRHAGE; CONTRACTILE PROTEINS; INCREASED EXPRESSION; SHORTENING VELOCITY;

D O I：

10.1111/j.1582-4934.2008.00508.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calponin (Cp) is an actin-binding protein first characterized in chicken gizzard smooth muscle (SM). This review discusses the role of Cp in mediating SM contraction, the biochemical process by which Cp facilitates SM contraction and the function of Cp in the brain. Recent work on the role of Cp in pathological states with emphasis on traumatic brain injury is also discussed. Based on past and present data, the case is presented for targeting Cp for novel genetic and pharmacological therapies aimed at improving outcome following traumatic brain injury (TBI).

引用

页码：262 / 269

页数：8

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