Blocking mu-opioid receptors inhibits social bonding in rituals

被引:26
作者
Charles, S. J. [1 ]
Farias, M. [1 ]
van Mulukom, V. [1 ]
Saraswati, A. [2 ]
Dein, S. [3 ]
Watts, F. [4 ]
Dunbar, R. I. M. [5 ]
机构
[1] Coventry Univ, Ctr Trust Peace & Social Relat, Brain Belief & Behav Lab, Cheetah Rd, Coventry CV1 2TL, W Midlands, England
[2] Tradit Yoga Assoc, Reading RG30 3DW, Berks, England
[3] Queen Mary Univ London, Dept Mental Hlth, London E1 4NS, England
[4] Int Soc Sci & Relig, Cambridge, England
[5] Univ Oxford, Dept Expt Psychol, Oxford, England
关键词
mu-opioids; social bonding; naltrexone; ritual; ritual bonding; EXTREME RITUALS; PAIN THRESHOLD; SYNCHRONY; NALTREXONE; BRAIN; ATTACHMENT; DOPAMINE; EFFICACY; SCALE;
D O I
10.1098/rsbl.2020.0485
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Religious rituals are universal human practices that play a seminal role in community bonding. In two experiments, we tested the role of mu-opioids as the active factor fostering social bonding. We used a mu-opioid blocker (naltrexone) in two double-blind studies of rituals from different religious traditions. We found the same effect across both studies, with naltrexone leading to significantly lower social bonding compared with placebo. These studies suggest that mu-opioids play a significant role in experiences of social bonding within ritual contexts.
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页数:5
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共 49 条
[21]   Opioids and social bonding: naltrexone reduces feelings of social connection [J].
Inagaki, Tristen K. ;
Ray, Lara A. ;
Irwin, Michael R. ;
Way, Baldwin M. ;
Eisenberger, Naomi I. .
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2016, 11 (05) :728-735
[22]   Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats [J].
Kohli, Shivali ;
King, Madeleine V. ;
Williams, Stuart ;
Edwards, Adele ;
Ballard, Theresa M. ;
Steward, Lucinda J. ;
Alberati, Daniella ;
Fone, Kevin C. F. .
NEUROPSYCHOPHARMACOLOGY, 2019, 44 (02) :295-305
[23]   Synchrony as an Adaptive Mechanism for Large-Scale Human Social Bonding [J].
Launay, Jacques ;
Tarr, Bronwyn ;
Dunbar, Robin I. M. .
ETHOLOGY, 2016, 122 (10) :779-789
[24]   The Effect of Group Size and Synchrony on Pain Threshold Changes [J].
Lewis, Zachary ;
Sullivan, Philip J. .
SMALL GROUP RESEARCH, 2018, 49 (06) :723-738
[25]   State-dependent μ-opioid modulation of social motivation [J].
Loseth, Guro E. ;
Ellingsen, Dan-Mikael ;
Leknes, Siri .
FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2014, 8
[26]   The brain opioid theory of social attachment: a review of the evidence [J].
Machin, A. J. ;
Dunbar, R. I. M. .
BEHAVIOUR, 2011, 148 (9-10) :985-1025
[27]   nparLD: An R Software Package for the Nonparametric Analysis of Longitudinal Data in Factorial Experiments [J].
Noguchi, Kimihiro ;
Gel, Yulia R. ;
Brunner, Edgar ;
Konietschke, Frank .
JOURNAL OF STATISTICAL SOFTWARE, 2012, 50 (12) :1-23
[28]   Social touch modulates endogenous μ-opioid system activity in humans [J].
Nummenmaa, Lauri ;
Tuominen, Lauri ;
Dunbar, Robin ;
Hirvonen, Jussi ;
Manninen, Sandra ;
Arponen, Eveliina ;
Machin, Anna ;
Hari, Riitta ;
Jaaskelainen, Iiro P. ;
Sams, Mikko .
NEUROIMAGE, 2016, 138 :242-247
[29]   ENDOGENOUS OPIOIDS AND SOCIAL-BEHAVIOR [J].
PANKSEPP, J ;
HERMAN, BH ;
VILBERG, T ;
BISHOP, P ;
DEESKINAZI, FG .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1980, 4 (04) :473-487
[30]   The Influence of Genetic Variation on Social Disposition, Romantic Relationships and Social Networks: a Replication Study [J].
Pearce E. ;
Wlodarski R. ;
Machin A. ;
Dunbar R.I.M. .
Adaptive Human Behavior and Physiology, 2018, 4 (4) :400-422