Alu repeats and human genomic diversity

被引：1046

作者：

Batzer, MA

Deininger, PL

机构：

[1] Louisiana State Univ, Biol Computat & Visualizat Ctr, Dept Biol Sci, Baton Rouge, LA 70803 USA

[2] Tulane Univ, Hlth Sci Ctr, Dept Environm Hlth Sci, Tulane Canc Ctr, New Orleans, LA 70112 USA

[3] Alton Ochsner Med Fdn & Ochsner Clin, Mol Genet Lab, New Orleans, LA 70121 USA

来源：

NATURE REVIEWS GENETICS | 2002年 / 3卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg798

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

During the past 65 million years, Alu elements have propagated to more than one million copies in primate genomes, which has resulted in the generation of a series of Alu subfamilies of different ages. Alu elements affect the genome in several ways, causing insertion mutations, recombination between elements, gene conversion and alterations in gene expression. Alu-insertion polymorphisms are a boon for the study of human population genetics and primate comparative genomics because they are neutral genetic markers of identical descent with known ancestral states.

引用

页码：370 / 379

页数：10

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