Prevention of UVB-Induced Production of the Inflammatory Mediator in Human Keratinocytes by Lactic Acid Derivatives Generated from Aromatic Amino Acids

被引：18

作者：

Aoki-Yoshida, Ayako ^{[1
,2
]}

Ichida, Kasumi ^{[1
,3
]}

Aoki, Reiji ^{[1
]}

Kawasumi, Toshiyuki ^{[3
]}

Suzuki, Chise ^{[1
]}

Takayama, Yoshiharu ^{[1
]}

机构：

[1] Natl Agr & Food Res Org, Inst Livestock & Grassland Sci, Funct Biomol Res Grp, Tsukuba, Ibaraki 3050901, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, Tokyo 1138657, Japan

[3] Japan Womens Univ, Fac Home Econ, Bunkyo Ku, Tokyo 1128681, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2013年 / 77卷 / 08期

关键词：

aromatic amino acid; 4-hydroxyphenyllactic acid; indole-3-lactic acid; interleukin-6 (IL-6); keratinocyte; CATABOLISM; PATHWAYS;

D O I：

10.1271/bbb.120979

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The anti-inflammatory effects of lactic acid derivatives were investigated on ultraviolet B (UVB)-irradiated HaCaT human keratinocytes. A pretreatment with indole-3-lactic acid (ILA) and 4-hydroxyphenyllactic acid (HPLA) inhibited the UVB-induced production of interlekin-6 (IL-6). The inhibitory effect of L-HPLA was equivalent to that of a corresponding racemic mixture (DL-HPLA), suggesting that optical isomerism did not affect the anti-inflammatory activity of HPLA.

引用

页码：1766 / 1768

页数：3

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