The Reset Hypothesis: Lactation and Maternal Metabolism

被引：216

作者：

Stuebe, Alison M. ^{[1
]}

Rich-Edwards, Janet W. ^{[2
,3
]}

机构：

[1] Univ N Carolina, Sch Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, Chapel Hill, NC 27599 USA

[2] Harvard Univ, Sch Publ Hlth, Brigham & Womens Hosp, Connors Ctr Womens Hlth & Gender Biol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 2009年 / 26卷 / 01期

关键词：

Lactation; adiposity; glucose homeostasis; hyperlipidemia; diabetes; metabolic syndrome; BODY-COMPOSITION CHANGES; HEALTHY SWEDISH WOMEN; LONG-TERM OBESITY; WEIGHT CHANGE; ANTHROPOMETRIC CHANGES; CARCASS COMPOSITION; LIPOPROTEIN-LIPASE; LIPID-METABOLISM; FAT DISTRIBUTION; ADIPOSE-TISSUE;

D O I：

10.1055/s-0028-1103034

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

For maternal metabolism, pregnancy ends not with delivery, but with weaning. In several recent epidemiological studies, authors have reported an association between duration of breast-feeding and reduced maternal risk of metabolic disease. These findings parallel data from animal models showing favorable changes in metabolism associated with lactation. During gestation, visceral fat accumulates, and insulin resistance and lipid and triglyceride levels increase. These changes appear to reverse more quickly, and more completely, with lactation. In this article, we review animal and human studies regarding the effects of lactation on adiposity, lipid, and glucose homeostasis. We hypothesize that lactation plays an important role in "resetting" maternal metabolism after pregnancy.

引用

页码：81 / 88

页数：8

共 67 条

[1]

[Anonymous], HLTH US 2005 CHARTB

[2] High prepregnant body mass index is associated with early termination of full and any breastfeeding in Danish women [J].