Optimization of α-tocopherol loaded solid lipid nanoparticles by central composite design

被引：66
作者：
de Carvalho, Sabrina Matos [1 ]
Noronha, Carolina Montanheiro [1 ]
Floriani, Caroline Louise [1 ]
Lino, Renata Calegari [1 ]
Rocha, Gabriela [1 ]
Bellettini, Ismael Casagrande [2 ]
Ogliari, Paulo Jose [1 ,3 ]
Manique Barreto, Pedro Luiz [1 ]
机构：
[1] Univ Fed Santa Catarina, Dept Ciencia & Tecnol Alimentos, BR-88034001 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil
[3] Univ Fed Santa Catarina, Dept Informat & Estat, BR-88040900 Florianopolis, SC, Brazil
来源：
INDUSTRIAL CROPS AND PRODUCTS | 2013年 / 49卷
关键词：
Surface response design; Solid lipid nanoparticle; Antioxidant; High-pressure homogenization; CONTROLLED DRUG-DELIVERY; OXIDATIVE STABILITY; VITAMIN-E; X-RAY; ANTIOXIDANTS; SLN; RELEASE; SYSTEMS; MICROENCAPSULATION; NANODISPERSIONS;
D O I：
10.1016/j.indcrop.2013.04.054
中图分类号：
S2 [农业工程];
学科分类号：
0828 ;
摘要：
Solid lipid nanoparticle (SLN) systems were developed using response surface methodology to optimize the mean particle size, alpha-tocopherol recovery rate and zeta potential of SLNs containing alpha-tocopherol. The optimization of alpha-tocopherol-loaded SLNs was characterized by X-ray diffraction analysis, differential scanning calorimetry, and the analysis of morphology and physical stability. The optimal conditions for an alpha-tocopherol-loaded SLN preparation were a particle size, alpha-tocopherol recovery rate and zeta potential of 214.5 nm, 75.4% and -41.9 mV, respectively; this preparation was stable during storage at 6 degrees C for 21 days. Furthermore, Compritol (R) 888 CG ATO changed its crystalline nature from the beta' polymorphic form in the pure formulation to the a and beta' polymorphic forms in SLNs. (C) 2013 Elsevier B.V. All rights reserved.
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收藏
页码：278 / 285
页数：8
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