Characterization of Acute and Chronic Hepatitis B Virus Genotypes in Canada

被引：18
作者：
Osiowy, Carla [1 ]
Giles, Elizabeth [1 ]
Trubnikov, Max [2 ]
Choudhri, Yogesh [2 ]
Andonov, Anton [1 ]
机构：
[1] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada
[2] Publ Hlth Agcy Canada, Ctr Communicable Dis & Infect Control, Ottawa, ON, Canada
来源：
PLOS ONE | 2015年 / 10卷 / 09期
关键词：
MOLECULAR EPIDEMIOLOGY; CHRONIC INFECTION; UNITED-STATES; RISK-FACTORS; PREVALENCE; MUTATIONS; DIVERSITY; MUTANTS; ENGLAND; IMPACT;
D O I：
10.1371/journal.pone.0136074
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Objective The prevalence and distribution of hepatitis B virus (HBV) genotypes in Canada is not known. Genotypic analysis may contribute to a better understanding of HBV strain distribution and transmission risk. Methods HBV surface antigen (HBsAg) positive samples of acute (n = 152) and chronic (n = 1533) HBV submitted for strain analysis or reference genotype testing between 2006 and 2012 were analyzed. The HBsAg coding region was amplified to determine the HBV genotype by INNO-LiPA assay or sequence analysis. Single and multivariate analyses were used to describe genotypes' associations with known demographic and behavioral risk factors for 126 linked cases of acute HBV. Results Nine genotypes were detected (A to I), including mixed infections. Genotype C (HBV/C) dominated within chronic infections while HBV/D and A prevailed among acute HBV cases. History of incarceration and residing with a chronic HBV carrier or injection drug user were the most frequently reported risks for acute HBV infection. Over time, HBV/A increased among both acute and chronic infections, and HBV/C and HBV/D decreased among chronic infections. Conclusion Chronic and acute HBV genotypes in Canada differ in the relative distribution and their associations with known risk factors, suggesting different routes of transmission and clinical progression of infection.
引用
收藏
页数：20
相关论文
共 55 条
[51]   Disease burden of chronic hepatitis B among immigrants in Canada [J].
Wong, William W. L. ;
Woo, Gloria ;
Heathcote, E. Jenny ;
Krahn, Murray .
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2013, 27 (03) :137-147
[52]  
Wu H X, 2005, Int J Med Sci, V2, P143
[53]   Dynamic Epidemiology of Acute Viral Hepatitis in Japan [J].
Yano, Koji ;
Tamada, Yoko ;
Yatsuhashi, Hiroshi ;
Komori, Atsumasa ;
Abiru, Seigo ;
Ito, Kiyoaki ;
Masaki, Naohiko ;
Mizokami, Masashi ;
Ishibashi, Hiromi .
INTERVIROLOGY, 2010, 53 (01) :70-75
[54]   High Levels of Hepatitis B Virus After the Onset of Disease Lead to Chronic Infection in Patients With Acute Hepatitis B [J].
Yotsuyanagi, Hiroshi ;
Ito, Kiyoaki ;
Yamada, Norie ;
Takahashi, Hideaki ;
Okuse, Chiaki ;
Yasuda, Kiyomi ;
Suzuki, Michihiro ;
Moriya, Kyoji ;
Mizokami, Masashi ;
Miyakawa, Yuzo ;
Koike, Kazuhiko .
CLINICAL INFECTIOUS DISEASES, 2013, 57 (07) :935-942
[55]   Risk factors for acute hepatitis B and its progression to chronic hepatitis in Shanghai, China [J].
Zhang, H. W. ;
Yin, J. H. ;
Li, Y. T. ;
Li, C. Z. ;
Ren, H. ;
Gu, C. Y. ;
Wu, H. Y. ;
Liang, X. S. ;
Zhang, P. ;
Zhao, J. F. ;
Tan, X. J. ;
Lu, W. ;
Schaefer, S. ;
Cao, G. W. .
GUT, 2008, 57 (12) :1713-1720
123456